Next Article in Journal
Antioxidant, Anti-Inflammatory, and Antidiabetic Activities of Leaves and Stems of Uapaca bojeri Bail. (EUPHORBIACEAE), an Endemic Plant of Madagascar
Previous Article in Journal
Evaluation of the Anti-Tumor Activity of Small Molecules Targeting Eph/Ephrins in APC min/J Mice
Open AccessArticle

Electroanalysis Applied to Compatibility and Stability Assays of Drugs: Carvedilol Study Case

1
Faculty of Pharmacy, Federal University of Goiás, Goiânia 74605-170, Brazil
2
Pharmacy School, Federal University of São João del-Rei, Midwest Campus, Divinópolis–MG, ZIP 35.501-296, Brazil
3
Universidade Paulista, Goiânia, GO 74845-090, Brazil
4
Department of Chemistry, Faculty of Applied Sciences, Cape Peninsula University of Technology, Bellville 7535, South Africa
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2020, 13(4), 70; https://doi.org/10.3390/ph13040070
Received: 2 March 2020 / Revised: 20 March 2020 / Accepted: 26 March 2020 / Published: 17 April 2020
(This article belongs to the Section Pharmaceutical Technology)
Carvedilol (CRV) is a non-selective blocker of α and β adrenergic receptors, which has been extensively used for the treatment of hypertension and congestive heart failure. Owing to its poor biopharmaceutical properties, CRV has been incorporated into different types of drug delivery systems and this necessitates the importance of investigating their compatibility and stability. In this sense, we have investigated the applicability of several electroanalytical tools to assess CRV compatibility with lipid excipients. Voltammetric and electrochemical impedance spectroscopy techniques were used to evaluate the redox behavior of CRV and lipid excipients. Results showed that Plurol® isostearic, liquid excipient, and stearic acid presented the greatest anode peak potential variation, and these were considered suitable excipients for CRV formulation. CRV showed the highest stability at room temperature and at 50 °C when mixed with stearic acid (7% w/w). The results also provided evidence that electrochemical methods might be feasible to complement standard stability/compatibility studies related to redox reactions. View Full-Text
Keywords: anti-hypertensives; drug delivery systems; electrochemical impedance spectroscopy; electrochemistry; excipients; pharmaceutical technology anti-hypertensives; drug delivery systems; electrochemical impedance spectroscopy; electrochemistry; excipients; pharmaceutical technology
Show Figures

Figure 1

MDPI and ACS Style

de Carvalho, M.F.; Garcia, L.F.; de Macedo, I.Y.L.; Marreto, R.N.; de Oliveira, M.T.; do Couto, R.O.; da Cunha, C.E.P.; de Siqueira Leite, K.C.; Rezende, K.R.; Machado, F.B.; Somerset, V.; Gil, E.S. Electroanalysis Applied to Compatibility and Stability Assays of Drugs: Carvedilol Study Case. Pharmaceuticals 2020, 13, 70.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop