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Communication

Nano-Interstice Driven Powerless Blood Plasma Extraction in a Membrane Filter Integrated Microfluidic Device

1
School of Mechanical Engineering, Korea University, Seoul 02841, Korea
2
Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
3
Department of Electrical Engineering, School of Electronics and Information Technology, Kwangwoon University, Seoul 01886, Korea
4
Absology, Digitalempire B-dong, 383, Simin-daero, Dongan-gu, Anyang-si, Gyeonggi-do 14057, Korea
5
KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 02841, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Antonio Jesus Torralba Silgado
Sensors 2021, 21(4), 1366; https://doi.org/10.3390/s21041366
Received: 12 January 2021 / Revised: 9 February 2021 / Accepted: 10 February 2021 / Published: 15 February 2021
(This article belongs to the Special Issue Integrated Circuits, Systems, Sensors and Their Applications)
Blood plasma is a source of biomarkers in blood and a simple, fast, and easy extraction method is highly required for point-of-care testing (POCT) applications. This paper proposes a membrane filter integrated microfluidic device to extract blood plasma from whole blood, without any external instrumentation. A commercially available membrane filter was integrated with a newly designed dual-cover microfluidic device to avoid leakage of the extracted plasma and remaining blood cells. Nano-interstices installed on both sides of the microfluidic channels actively draw the extracted plasma from the membrane. The developed device successfully supplied 20 μL of extracted plasma with a high extraction yield (~45%) in 16 min. View Full-Text
Keywords: microfluidics; point-of-care testing; blood plasma extraction microfluidics; point-of-care testing; blood plasma extraction
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MDPI and ACS Style

Kim, J.; Yoon, J.; Byun, J.-Y.; Kim, H.; Han, S.; Kim, J.; Lee, J.H.; Jo, H.-S.; Chung, S. Nano-Interstice Driven Powerless Blood Plasma Extraction in a Membrane Filter Integrated Microfluidic Device. Sensors 2021, 21, 1366. https://doi.org/10.3390/s21041366

AMA Style

Kim J, Yoon J, Byun J-Y, Kim H, Han S, Kim J, Lee JH, Jo H-S, Chung S. Nano-Interstice Driven Powerless Blood Plasma Extraction in a Membrane Filter Integrated Microfluidic Device. Sensors. 2021; 21(4):1366. https://doi.org/10.3390/s21041366

Chicago/Turabian Style

Kim, Jaehoon, Junghyo Yoon, Jae-Yeong Byun, Hyunho Kim, Sewoon Han, Junghyun Kim, Jeong H. Lee, Han-Sang Jo, and Seok Chung. 2021. "Nano-Interstice Driven Powerless Blood Plasma Extraction in a Membrane Filter Integrated Microfluidic Device" Sensors 21, no. 4: 1366. https://doi.org/10.3390/s21041366

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