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Coupling Single-Drop Microextraction with SERS: A Demonstration Using p-MBA on Gold Nanohole Array Substrate

1
LQANano, Federal University of São Paulo, São José dos Campos-SP, 12231-280, Brazil
2
Engineering Department, Federal University of Pampa, Alegrete-RS, 97546-550, Brazil
3
Applied Optics Laboratory–School of Technology, State University of Campinas, Limeira–SP, 13484-350, Brazil
*
Author to whom correspondence should be addressed.
Sensors 2019, 19(20), 4394; https://doi.org/10.3390/s19204394
Received: 10 August 2019 / Revised: 28 August 2019 / Accepted: 19 September 2019 / Published: 11 October 2019
(This article belongs to the Section Optical Sensors)
Single-drop microextraction (SDME) was coupled with surface-enhanced Raman scattering (SERS) to provide sample extraction and pre-concentration for detection of analyte at low concentrations. A gold nanohole array substrate (AuNHAS), fabricated by interference lithography, was used as SERS substrate and para-mercaptobenzoic acid (p-MBA) was tested as a probe molecule, in the concentration range 10−8–10−4 mol L−1. With this approach, a limit of 10−7 mol L−1 was clearly detected. To improve the detection to lower p-MBA concentration, as 10−8 mol L−1, the SDME technique was applied. The p-MBA Raman signature was detected in two performed extractions and its new concentration was determined to be ~4.6 × 10−5 mol L−1. This work showed that coupling SDME with SERS allowed a rapid (5 min) and efficient pre-concentration (from 10−8 mol L−1 to 10−5 mol L−1), detection, and quantification of the analyte of interest, proving to be an interesting analytical tool for SERS applications. View Full-Text
Keywords: gold nanohole array; interference lithography; pre-concentration; Raman signature; low concentration detection gold nanohole array; interference lithography; pre-concentration; Raman signature; low concentration detection
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Santos, E.B.; Valsecchi, C.; Gonçalves, J.L.S.; Ávila, L.F.; Menezes, J.W. Coupling Single-Drop Microextraction with SERS: A Demonstration Using p-MBA on Gold Nanohole Array Substrate. Sensors 2019, 19, 4394.

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