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Erratum published on 7 March 2019, see Sensors 2019, 19(5), 1161.
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Silicon Photonic Biosensors Using Label-Free Detection

1
Department of Electrical and Computer Engineering, University of British Columbia, 2329 West Mall, Vancouver, BC V6T 1Z4, Canada
2
Department of Bioengineering, University of Washington, 3720 15th Ave. NE, Seattle, WA 98195-5061, USA
*
Author to whom correspondence should be addressed.
Sensors 2018, 18(10), 3519; https://doi.org/10.3390/s18103519
Received: 7 September 2018 / Revised: 9 October 2018 / Accepted: 15 October 2018 / Published: 18 October 2018
(This article belongs to the Section Physical Sensors)
Thanks to advanced semiconductor microfabrication technology, chip-scale integration and miniaturization of lab-on-a-chip components, silicon-based optical biosensors have made significant progress for the purpose of point-of-care diagnosis. In this review, we provide an overview of the state-of-the-art in evanescent field biosensing technologies including interferometer, microcavity, photonic crystal, and Bragg grating waveguide-based sensors. Their sensing mechanisms and sensor performances, as well as real biomarkers for label-free detection, are exhibited and compared. We also review the development of chip-level integration for lab-on-a-chip photonic sensing platforms, which consist of the optical sensing device, flow delivery system, optical input and readout equipment. At last, some advanced system-level complementary metal-oxide semiconductor (CMOS) chip packaging examples are presented, indicating the commercialization potential for the low cost, high yield, portable biosensing platform leveraging CMOS processes. View Full-Text
Keywords: silicon photonics; evanescent optical field sensor; label-free SOI biosensor; Mach–Zehnder interferometer; ring resonator; photonic crystal; Bragg grating; sub-wavelength grating; lab-on-a-chip; microfluidics silicon photonics; evanescent optical field sensor; label-free SOI biosensor; Mach–Zehnder interferometer; ring resonator; photonic crystal; Bragg grating; sub-wavelength grating; lab-on-a-chip; microfluidics
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Luan, E.; Shoman, H.; Ratner, D.M.; Cheung, K.C.; Chrostowski, L. Silicon Photonic Biosensors Using Label-Free Detection. Sensors 2018, 18, 3519.

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