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Open AccessArticle

Electrochemical Detection of Dopamine Using 3D Porous Graphene Oxide/Gold Nanoparticle Composites

1
School of Integrative Engineering, Chung-Ang University, Seoul 06974, Korea
2
Department of Chemical and Biomolecular Engineering, Sogang University, Seoul 04109, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Nathan Lindquist, Nathan Wittenberg and Sang-Hyun Oh
Sensors 2017, 17(4), 861; https://doi.org/10.3390/s17040861
Received: 2 March 2017 / Revised: 6 April 2017 / Accepted: 11 April 2017 / Published: 14 April 2017
(This article belongs to the Special Issue Micro and Nanofabrication Technologies for Biosensors)
The detection of dopamine in a highly sensitive and selective manner is crucial for the early diagnosis of a number of neurological diseases/disorders. Here, a report on a new platform for the electrochemical detection of dopamine with a considerable accuracy that comprises a 3D porous graphene oxide (pGO)/gold nanoparticle (GNP)/pGO composite-modified indium tin oxide (ITO) is presented. The pGO was first synthesized and purified by ultrasonication and centrifugation, and it was then further functionalized on the surface of a GNP-immobilized ITO electrode. Remarkably, owing to the synergistic effects of the pGO and GNPs, the 3D pGO-GNP-pGO-modified ITO electrode showed a superior dopamine-detection performance compared with the other pGO- or GNP-modified ITO electrodes. The linear range of the newly developed sensing platform is from 0.1 μM to 30 μM with a limit of detection (LOD) of 1.28 μM, which is more precise than the other previously reported GO-functionalized electrodes. Moreover, the 3D pGO-GNP-pGO-modified ITO electrodes maintained their detection capability even in the presence of several interfering molecules (e.g., ascorbic acid, glucose). The proposed platform of the 3D pGO-GNP-pGO-modified ITO electrode could therefore serve as a competent candidate for the development of a dopamine-sensing platform that is potentially applicable for the early diagnosis of various neurological diseases/disorders. View Full-Text
Keywords: graphene oxide; porous structure; gold nanoparticles; indium tin oxide; neurotransmitters; dopamine; composites; electrochemical detection graphene oxide; porous structure; gold nanoparticles; indium tin oxide; neurotransmitters; dopamine; composites; electrochemical detection
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MDPI and ACS Style

Choo, S.-S.; Kang, E.-S.; Song, I.; Lee, D.; Choi, J.-W.; Kim, T.-H. Electrochemical Detection of Dopamine Using 3D Porous Graphene Oxide/Gold Nanoparticle Composites. Sensors 2017, 17, 861. https://doi.org/10.3390/s17040861

AMA Style

Choo S-S, Kang E-S, Song I, Lee D, Choi J-W, Kim T-H. Electrochemical Detection of Dopamine Using 3D Porous Graphene Oxide/Gold Nanoparticle Composites. Sensors. 2017; 17(4):861. https://doi.org/10.3390/s17040861

Chicago/Turabian Style

Choo, Sung-Sik; Kang, Ee-Seul; Song, Inbeom; Lee, Donghyun; Choi, Jeong-Woo; Kim, Tae-Hyung. 2017. "Electrochemical Detection of Dopamine Using 3D Porous Graphene Oxide/Gold Nanoparticle Composites" Sensors 17, no. 4: 861. https://doi.org/10.3390/s17040861

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