Electrochemical Detection of Dopamine Using 3D Porous Graphene Oxide/Gold Nanoparticle Composites
AbstractThe detection of dopamine in a highly sensitive and selective manner is crucial for the early diagnosis of a number of neurological diseases/disorders. Here, a report on a new platform for the electrochemical detection of dopamine with a considerable accuracy that comprises a 3D porous graphene oxide (pGO)/gold nanoparticle (GNP)/pGO composite-modified indium tin oxide (ITO) is presented. The pGO was first synthesized and purified by ultrasonication and centrifugation, and it was then further functionalized on the surface of a GNP-immobilized ITO electrode. Remarkably, owing to the synergistic effects of the pGO and GNPs, the 3D pGO-GNP-pGO-modified ITO electrode showed a superior dopamine-detection performance compared with the other pGO- or GNP-modified ITO electrodes. The linear range of the newly developed sensing platform is from 0.1 μM to 30 μM with a limit of detection (LOD) of 1.28 μM, which is more precise than the other previously reported GO-functionalized electrodes. Moreover, the 3D pGO-GNP-pGO-modified ITO electrodes maintained their detection capability even in the presence of several interfering molecules (e.g., ascorbic acid, glucose). The proposed platform of the 3D pGO-GNP-pGO-modified ITO electrode could therefore serve as a competent candidate for the development of a dopamine-sensing platform that is potentially applicable for the early diagnosis of various neurological diseases/disorders. View Full-Text
- Supplementary File 1:
PDF-Document (PDF, 1348 KB)
Share & Cite This Article
Choo, S.-S.; Kang, E.-S.; Song, I.; Lee, D.; Choi, J.-W.; Kim, T.-H. Electrochemical Detection of Dopamine Using 3D Porous Graphene Oxide/Gold Nanoparticle Composites. Sensors 2017, 17, 861.
Choo S-S, Kang E-S, Song I, Lee D, Choi J-W, Kim T-H. Electrochemical Detection of Dopamine Using 3D Porous Graphene Oxide/Gold Nanoparticle Composites. Sensors. 2017; 17(4):861.Chicago/Turabian Style
Choo, Sung-Sik; Kang, Ee-Seul; Song, Inbeom; Lee, Donghyun; Choi, Jeong-Woo; Kim, Tae-Hyung. 2017. "Electrochemical Detection of Dopamine Using 3D Porous Graphene Oxide/Gold Nanoparticle Composites." Sensors 17, no. 4: 861.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.