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Sensors 2017, 17(12), 2962; https://doi.org/10.3390/s17122962

Quantitative and Sensitive Detection of Chloramphenicol by Surface-Enhanced Raman Scattering

1
Beijing Key Laboratory of Bioprocess, Beijing University of Chemical Technology, Beijing 100029, China
2
College of Science, Beijing University of Chemical Technology, Beijing 100029, China
3
Engineering Research Center for Semiconductor Integrated Technology, Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, China
4
Analytical and Testing Center, Beijing Normal University, Beijing 100875, China
*
Authors to whom correspondence should be addressed.
Received: 23 October 2017 / Revised: 3 December 2017 / Accepted: 5 December 2017 / Published: 20 December 2017
(This article belongs to the Special Issue Surface Plasmon Resonance Sensing)
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Abstract

We used surface-enhanced Raman scattering (SERS) for the quantitative and sensitive detection of chloramphenicol (CAP). Using 30 nm colloidal Au nanoparticles (NPs), a low detection limit for CAP of 10−8 M was obtained. The characteristic Raman peak of CAP centered at 1344 cm−1 was used for the rapid quantitative detection of CAP in three different types of CAP eye drops, and the accuracy of the measurement result was verified by high-performance liquid chromatography (HPLC). The experimental results reveal that the SERS technique based on colloidal Au NPs is accurate and sensitive, and can be used for the rapid detection of various antibiotics. View Full-Text
Keywords: surface-enhanced Raman scattering; Au nanoparticles; chloramphenicol; quantitative detection surface-enhanced Raman scattering; Au nanoparticles; chloramphenicol; quantitative detection
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Ding, Y.; Zhang, X.; Yin, H.; Meng, Q.; Zhao, Y.; Liu, L.; Wu, Z.; Xu, H. Quantitative and Sensitive Detection of Chloramphenicol by Surface-Enhanced Raman Scattering. Sensors 2017, 17, 2962.

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