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Sensors 2015, 15(8), 19912-19924;

Quadruplex Integrated DNA (QuID) Nanosensors for Monitoring Dopamine

Department of Pharmaceutical Sciences, Northeastern University, 206 The Fenway, 360 Huntington Avenue, Boston, MA 02115, USA
Author to whom correspondence should be addressed.
Academic Editor: Frances S. Ligler
Received: 27 June 2015 / Revised: 30 July 2015 / Accepted: 10 August 2015 / Published: 13 August 2015
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Dopamine is widely innervated throughout the brain and critical for many cognitive and motor functions. Imbalances or loss in dopamine transmission underlie various psychiatric disorders and degenerative diseases. Research involving cellular studies and disease states would benefit from a tool for measuring dopamine transmission. Here we show a Quadruplex Integrated DNA (QuID) nanosensor platform for selective and dynamic detection of dopamine. This nanosensor exploits DNA technology and enzyme recognition systems to optically image dopamine levels. The DNA quadruplex architecture is designed to be compatible in physically constrained environments (110 nm) with high flexibility, homogeneity, and a lower detection limit of 110 µM. View Full-Text
Keywords: dopamine; tyrosinase; enzyme; nanosensor; DNA; dendrimer dopamine; tyrosinase; enzyme; nanosensor; DNA; dendrimer

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Morales, J.M.; Skipwith, C.G.; Clark, H.A. Quadruplex Integrated DNA (QuID) Nanosensors for Monitoring Dopamine. Sensors 2015, 15, 19912-19924.

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