Open AccessReview
Fully Integrated Biochip Platforms for Advanced Healthcare
by
Sandro Carrara 1,*, Sara Ghoreishizadeh 1, Jacopo Olivo 1, Irene Taurino 1, Camilla Baj-Rossi 1, Andrea Cavallini 1, Maaike Op de Beeck 2, Catherine Dehollain 1, Wayne Burleson 3, Francis Gabriel Moussy 4, Anthony Guiseppi-Elie 5,6 and Giovanni De Micheli 1
1
École Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland
2
Interuniversity Microelectronics Centre (IMEC), B-3001 Leuven, Belgium
3
Department of Electrical and Computer Engineering, University of Massachusetts, Amherst, MA 01003, USA
4
Brunel Institute for Bioengineering, University of Brunel, West London, UB8 3PH, UK
5
Department of Electrical and Computer Engineering, Center for Bioelectronics, Biosensors and Biochips, Clemson University, Anderson, SC 29625, USA
6
ABTECH Scientific, Inc., Richmond, VA 23219, USA
Cited by 70 | Viewed by 16810
Abstract
Recent advances in microelectronics and biosensors are enabling developments of innovative biochips for advanced healthcare by providing fully integrated platforms for continuous monitoring of a large set of human disease biomarkers. Continuous monitoring of several human metabolites can be addressed by using fully
[...] Read more.
Recent advances in microelectronics and biosensors are enabling developments of innovative biochips for advanced healthcare by providing fully integrated platforms for continuous monitoring of a large set of human disease biomarkers. Continuous monitoring of several human metabolites can be addressed by using fully integrated and minimally invasive devices located in the sub-cutis, typically in the peritoneal region. This extends the techniques of continuous monitoring of glucose currently being pursued with diabetic patients. However, several issues have to be considered in order to succeed in developing fully integrated and minimally invasive implantable devices. These innovative devices require a high-degree of integration, minimal invasive surgery, long-term biocompatibility, security and privacy in data transmission, high reliability, high reproducibility, high specificity, low detection limit and high sensitivity. Recent advances in the field have already proposed possible solutions for several of these issues. The aim of the present paper is to present a broad spectrum of recent results and to propose future directions of development in order to obtain fully implantable systems for the continuous monitoring of the human metabolism in advanced healthcare applications.
Full article
(This article belongs to the Special Issue
Biochips)
►▼
Show Figures