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Tetramethyl 1,1′-(2-[{4,5-bis(Methoxycarbonyl)-1H-1,2,3-triazol-1-yl}methyl]-2-[(4-methylphenyl)sulfonamido]propane-1,3-diyl)bis(1H-1,2,3-triazole-4,5-dicarboxylate)

1
Engineering Laboratory of Organometallic, Molecular Materials and Environment (LIMOME), Faculty of Sciences Dhar El Mahraz, Sidi Mohammed Ben Abdellah University, 30000 Fez, Morocco
2
Team of Organic Chemistry and Valorization of Natural Substances (COVSN), Faculty of Sciences, Ibn Zohr University, 80060 Agadir, Morocco
*
Author to whom correspondence should be addressed.
Academic Editor: Fawaz Aldabbagh
Molbank 2021, 2021(1), M1186; https://doi.org/10.3390/M1186
Received: 13 January 2021 / Revised: 26 January 2021 / Accepted: 27 January 2021 / Published: 31 January 2021
(This article belongs to the Special Issue Heterocycle Reactions)
A new compound tetramethyl 1,1′-(2-[{4,5-bis(methoxycarbonyl)-1H-1,2,3-triazol-1-yl}methyl]-2-[(4-methylphenyl)sulfonamido]propane-1,3-diyl)bis(1H-1,2,3-triazole-4,5-dicarboxylate) (3) was prepared in two steps starting from 2-((4-methylphenyl)sulfonamido)-2-((tosyloxy)methyl)propane-1,3-diylbis(4-methylbenzenesulfonate) (1), with an overall yield of 74%. The key step being the copper-free Huisgen cycloaddition between N-(1,3-diazido-2-(azidomethyl)propan-2-yl)-4-methylbenzenesulfonamide (2) and commercially available dimethyl acetylenedicarboxylate. The chemical structure of compound 3 was determined by IR, 1D and 2D NMR experiments, and elemental analysis. View Full-Text
Keywords: azide; nucleophilic substitution reaction; copper-free Huisgen reaction; 2D NMR experiments azide; nucleophilic substitution reaction; copper-free Huisgen reaction; 2D NMR experiments
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MDPI and ACS Style

Fall, S.A.K.; Hajib, S.; Karai, O.; Aouine, Y.; Boukhssas, S.; Faraj, H.; Alami, A. Tetramethyl 1,1′-(2-[{4,5-bis(Methoxycarbonyl)-1H-1,2,3-triazol-1-yl}methyl]-2-[(4-methylphenyl)sulfonamido]propane-1,3-diyl)bis(1H-1,2,3-triazole-4,5-dicarboxylate). Molbank 2021, 2021, M1186. https://doi.org/10.3390/M1186

AMA Style

Fall SAK, Hajib S, Karai O, Aouine Y, Boukhssas S, Faraj H, Alami A. Tetramethyl 1,1′-(2-[{4,5-bis(Methoxycarbonyl)-1H-1,2,3-triazol-1-yl}methyl]-2-[(4-methylphenyl)sulfonamido]propane-1,3-diyl)bis(1H-1,2,3-triazole-4,5-dicarboxylate). Molbank. 2021; 2021(1):M1186. https://doi.org/10.3390/M1186

Chicago/Turabian Style

Fall, Serigne A.K.; Hajib, Sara; Karai, Oumaima; Aouine, Younas; Boukhssas, Salaheddine; Faraj, Hassane; Alami, Anouar. 2021. "Tetramethyl 1,1′-(2-[{4,5-bis(Methoxycarbonyl)-1H-1,2,3-triazol-1-yl}methyl]-2-[(4-methylphenyl)sulfonamido]propane-1,3-diyl)bis(1H-1,2,3-triazole-4,5-dicarboxylate)" Molbank 2021, no. 1: M1186. https://doi.org/10.3390/M1186

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