Next Article in Journal
Microwave-Assisted Synthesis and Fluorescent Properties of 4-Phenyl-1,8-naphthalimide
Previous Article in Journal
Dimethyl 2-(1-methyl-3-oxo-1,3-dihydroisobenzofuran-1-yl)malonate

This is an early access version, the complete PDF, HTML, and XML versions will be available soon.

Open AccessCommunication

Improved Synthesis and Determination of the Biologically Active Diastereomer of YK11

Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan
*
Authors to whom correspondence should be addressed.
Molbank 2020, 2020(2), M1125; https://doi.org/10.3390/M1125
Received: 8 April 2020 / Revised: 18 April 2020 / Accepted: 20 April 2020 / Published: 21 April 2020
(This article belongs to the Section Organic Synthesis)
The palladium catalyzed carbonylation of 1 using the chiral ligand L1 afforded 2 in a highly diastereoselective manner. The stereochemistry of the major diastereomer 2a was determined by X-ray crystallographic analysis. AR luciferase reporter assay studies suggested that 2a was the active constituent of YK11 (2).
Keywords: YK11; SARMs; palladium; carbonylation; orthoester YK11; SARMs; palladium; carbonylation; orthoester
Show Figures

Graphical abstract

MDPI and ACS Style

Kanno, Y.; Kusakabe, T.; Saito, N.; Kikkawa, S.; Takahashi, K.; Azumaya, I.; Nemoto, K.; Kato, K. Improved Synthesis and Determination of the Biologically Active Diastereomer of YK11. Molbank 2020, 2020, M1125.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop