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Open AccessCommunication

1-[1-(4-Chlorobenzenesulfonyl)-1H-indole-3-yl]-3-[4-(pyridin-2-yl)piperazin-1-yl]propan-1-one

Laboratorio de Síntesis de Heterociclos Bioactivos, Departamento de Farmacia, Facultad de Química, Pontificia Universidad Católica de Chile, Casilla 306, Avda. Vicuña Mackenna 4860, Macul 7820436, Santiago, Chile
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Molbank 2018, 2018(2), M991; https://doi.org/10.3390/M991
Received: 17 March 2018 / Revised: 13 April 2018 / Accepted: 16 April 2018 / Published: 18 April 2018
(This article belongs to the Special Issue Heterocycles)
The title compound was prepared by an aza-Michael addition reaction between 1-[1-(4-chlorobenzenesulfonyl)-1H-indole-3-yl]prop-2-en-1-one and 2-piridylpiperazine catalyzed by SiO2. The structural identity of the title compound was proven by elemental analysis and spectroscopic methods (IR, NMR). The compound was assayed in a binding assay at the 5-HT6 receptor, showing poor affinity. View Full-Text
Keywords: aza-Michael addition; indole; serotonin; 5-HT6; arylpiperazine; arylsulfonylindole aza-Michael addition; indole; serotonin; 5-HT6; arylpiperazine; arylsulfonylindole
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Diethelm, B.; Almendras, S.; Recabarren-Gajardo, G. 1-[1-(4-Chlorobenzenesulfonyl)-1H-indole-3-yl]-3-[4-(pyridin-2-yl)piperazin-1-yl]propan-1-one. Molbank 2018, 2018, M991.

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