The Combined Potential of PRP and Osteoinductive Carrier Matrices for Bone Regeneration

Meglei, Anastasiia Yurevna; Nedorubova, Irina Alekseevna; Basina, Viktoriia Pavlovna; Chernomyrdina, Viktoria Olegovna; Goldshtein, Dmitry Vadimovich; Bukharova, Tatiana Borisovna

doi:10.3390/ijms26178457

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The Combined Potential of PRP and Osteoinductive Carrier Matrices for Bone Regeneration

by

Anastasiia Yurevna Meglei

,

Irina Alekseevna Nedorubova

^*

,

Viktoriia Pavlovna Basina

,

Viktoria Olegovna Chernomyrdina

,

Dmitry Vadimovich Goldshtein

and

Tatiana Borisovna Bukharova

Research Centre for Medical Genetics, 115478 Moscow, Russia

^*

Author to whom correspondence should be addressed.

Int. J. Mol. Sci. 2025, 26(17), 8457; https://doi.org/10.3390/ijms26178457 (registering DOI)

Submission received: 16 July 2025 / Revised: 28 August 2025 / Accepted: 28 August 2025 / Published: 30 August 2025

(This article belongs to the Special Issue Novel Insights into Regenerative Medicine)

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Abstract

In regenerative medicine, orthobiologics, particularly platelet-rich plasma (PRP), are widely used due to their ability to enhance natural tissue repair mechanisms. PRP contains a concentrated pool of growth factors and cytokines that enhance regeneration while also acting as a biomimetic scaffold, thereby optimizing the microenvironment for tissue healing. In bone tissue engineering, PRP is commonly combined with synthetic or natural biomaterials, as its fibrin matrix alone lacks sufficient mechanical stability. However, even such composite systems frequently exhibit limited osteoinductive capacity, necessitating further supplementation with bioactive components. This review evaluates the regenerative potential of PRP in bone defect healing when combined with osteoinductive agents in preclinical in vivo models. We present compelling experimental evidence supporting the efficacy of this combined therapeutic approach.

Keywords: PRP; PRF; biomaterials; MSCs; BMP-2; regenerative medicine; bone regeneration

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MDPI and ACS Style

Meglei, A.Y.; Nedorubova, I.A.; Basina, V.P.; Chernomyrdina, V.O.; Goldshtein, D.V.; Bukharova, T.B. The Combined Potential of PRP and Osteoinductive Carrier Matrices for Bone Regeneration. Int. J. Mol. Sci. 2025, 26, 8457. https://doi.org/10.3390/ijms26178457

AMA Style

Meglei AY, Nedorubova IA, Basina VP, Chernomyrdina VO, Goldshtein DV, Bukharova TB. The Combined Potential of PRP and Osteoinductive Carrier Matrices for Bone Regeneration. International Journal of Molecular Sciences. 2025; 26(17):8457. https://doi.org/10.3390/ijms26178457

Chicago/Turabian Style

Meglei, Anastasiia Yurevna, Irina Alekseevna Nedorubova, Viktoriia Pavlovna Basina, Viktoria Olegovna Chernomyrdina, Dmitry Vadimovich Goldshtein, and Tatiana Borisovna Bukharova. 2025. "The Combined Potential of PRP and Osteoinductive Carrier Matrices for Bone Regeneration" International Journal of Molecular Sciences 26, no. 17: 8457. https://doi.org/10.3390/ijms26178457

APA Style

Meglei, A. Y., Nedorubova, I. A., Basina, V. P., Chernomyrdina, V. O., Goldshtein, D. V., & Bukharova, T. B. (2025). The Combined Potential of PRP and Osteoinductive Carrier Matrices for Bone Regeneration. International Journal of Molecular Sciences, 26(17), 8457. https://doi.org/10.3390/ijms26178457

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The Combined Potential of PRP and Osteoinductive Carrier Matrices for Bone Regeneration

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