Uncovering Hidden Gluten Exposure in Celiac Patients: A Case Study in Family-Based Management and the Role of Point-of-Care Urine Testing and Psychological Assessment
Abstract
1. Introduction
2. Results
2.1. Patients
2.2. Clinical Follow-Up and Monitoring During CD Follow-Up Visit
2.2.1. Biochemical Evaluation
2.2.2. CD Antibodies and Duodenal Histology
2.2.3. Celiac Dietary Adherence Test (CDAT)
2.2.4. Symptomatology
2.2.5. Psychological Assessment of Adherence to the GFD
2.2.6. POCT-Based GIP Determination in Primary Care
3. Discussion
4. Materials and Methods
4.1. Study Design and Population
4.2. Urine and Blood Collection
4.3. CD Antibodies
4.4. Duodenal Histology
4.5. Celiac Dietary Adherence Test (CDAT)
4.6. Symptoms Questionnaire
4.7. The Hospital Anxiety Scale (HAS)
4.8. POCT-Based GIP Determination in Urine Samples
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
AGAs | Anti-gliadin antibodies |
Anti-DGP | Anti-deamidated gliadin antibodies |
anti-tTG | Tissue transglutaminase antibodies |
CD | Celiac disease |
CDAT | Celiac dietary adherence test |
GIP | Gluten immunogenic peptides |
GFD | Gluten-free diet |
HAS | Hospital Anxiety Scale |
POCT | Point-of-care testing |
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Ruiz-Carnicer, Á.; Coronel-Rodríguez, C.; Guisado-Rasco, M.C.; Comino, I.; Sousa, C.; Segura, V. Uncovering Hidden Gluten Exposure in Celiac Patients: A Case Study in Family-Based Management and the Role of Point-of-Care Urine Testing and Psychological Assessment. Int. J. Mol. Sci. 2025, 26, 5135. https://doi.org/10.3390/ijms26115135
Ruiz-Carnicer Á, Coronel-Rodríguez C, Guisado-Rasco MC, Comino I, Sousa C, Segura V. Uncovering Hidden Gluten Exposure in Celiac Patients: A Case Study in Family-Based Management and the Role of Point-of-Care Urine Testing and Psychological Assessment. International Journal of Molecular Sciences. 2025; 26(11):5135. https://doi.org/10.3390/ijms26115135
Chicago/Turabian StyleRuiz-Carnicer, Ángela, Cristóbal Coronel-Rodríguez, María Cinta Guisado-Rasco, Isabel Comino, Carolina Sousa, and Verónica Segura. 2025. "Uncovering Hidden Gluten Exposure in Celiac Patients: A Case Study in Family-Based Management and the Role of Point-of-Care Urine Testing and Psychological Assessment" International Journal of Molecular Sciences 26, no. 11: 5135. https://doi.org/10.3390/ijms26115135
APA StyleRuiz-Carnicer, Á., Coronel-Rodríguez, C., Guisado-Rasco, M. C., Comino, I., Sousa, C., & Segura, V. (2025). Uncovering Hidden Gluten Exposure in Celiac Patients: A Case Study in Family-Based Management and the Role of Point-of-Care Urine Testing and Psychological Assessment. International Journal of Molecular Sciences, 26(11), 5135. https://doi.org/10.3390/ijms26115135