Exploring Black Soybean Extract Cream for Inflammatory Dermatitis—Toward Radiation Dermatitis Relief
Abstract
1. Introduction
2. Results
3. Discussion
4. Materials and Methods
4.1. Study Medication and the Extraction Method
4.2. DNCB-Induced Dermatitis Animal Model and Dermatitis Severity Scoring
4.3. Enzyme-Linked Immunosorbent Assay (ELISA)
4.3.1. Cell Culture and ELISA
4.3.2. Mice and ELISA
4.4. Statistical Analysis
4.5. ARRIVE (Animal Research: Reporting of In Vivo Experiments) Checklist Compliance
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
- Wei, J.; Meng, L.; Hou, X.; Qu, C.; Wang, B.; Xin, Y.; Jiang, X. Radiation-induced skin reactions: Mechanism and treatment. Cancer Manag. Res. 2019, 11, 167–177. [Google Scholar] [CrossRef] [PubMed]
- Scharf, A. The effect of soybean lecithin on the stabilization and utilization of vitamin A and carotene soybean lecithin as a stabilizer of fat, vitamin A and carotene in foods and feeds. Food Mater. Equip. 1947, 7, 8. [Google Scholar] [PubMed]
- Kafer, J.M.; Molinari, M.D.C.; Henning, F.A.; Koltun, A.; Marques, V.V.; Marin, S.R.R.; Nepomuceno, A.L.; Mertz-Henning, L.M. Transcriptional Profile of Soybean Seeds with Contrasting Seed Coat Color. Plants 2023, 12, 1555. [Google Scholar] [CrossRef] [PubMed]
- Sohn, D.W.; Bae, W.J.; Kim, H.S.; Kim, S.W.; Kim, S.W. The Anti-inflammatory and Antifibrosis Effects of Anthocyanin Extracted From Black Soybean on a Peyronie Disease Rat Model. Urology 2014, 84, 1112–1116. [Google Scholar] [CrossRef]
- Lee, J.H.; Seo, E.Y.; Lee, Y.M. Comparative investigation on variations of nutritional components in whole seeds and seed coats of Korean black soybeans for different crop years and screening of their antioxidant and anti-aging properties. Food Chem. X 2023, 17, 100572. [Google Scholar] [CrossRef]
- Anjum, S.; Rana, S.; Dasila, K.; Agnihotri, V.; Pandey, A.; Pande, V. Comparative nutritional and antimicrobial analysis of Himalayan black and yellow soybean and their okara. J. Sci. Food Agric. 2022, 102, 5358–5367. [Google Scholar] [CrossRef]
- Na, T.-Y.; Kim, G.-H.; Oh, H.-J.; Lee, M.-H.; Han, Y.-H.; Kim, K.T.; Kim, J.-S.; Kim, D.-D.; Lee, M.-O. The trisaccharide raffinose modulates epidermal differentiation through activation of liver X receptor. Sci. Rep. 2017, 7, 43823. [Google Scholar] [CrossRef]
- Valsecchi, A.E.; Franchi, S.; Panerai, A.E.; Sacerdote, P.; Trovato, A.E.; Colleoni, M. Genistein, a natural phytoestrogen from soy, relieves neuropathic pain following chronic constriction sciatic nerve injury in mice: Anti-inflammatory and antioxidant activity. J. Neurochem. 2008, 107, 230–240. [Google Scholar] [CrossRef]
- Kim, H.J.; Xu, L.; Chang, K.C.; Shin, S.C.; Chung, J.I.; Kang, D.; Kim, S.-H.; Hur, J.A.; Choi, T.H.; Kim, S.; et al. Anti-inflammatory effects of anthocyanins from black soybean seed coat on the keratinocytes and ischemia-reperfusion injury in rat skin flaps. Microsurgery 2012, 32, 563–570. [Google Scholar] [CrossRef]
- Kim, J.-M.; Kim, K.-M.; Park, E.-H.; Seo, J.-H.; Song, J.-Y.; Shin, S.-C.; Kang, H.-L.; Lee, W.-K.; Cho, M.-J.; Rhee, K.-H.; et al. Anthocyanins from black soybean inhibit Helicobacter pylori-induced inflammation in human gastric epithelial AGS cells. Microbiol. Immunol. 2013, 57, 366–373. [Google Scholar] [CrossRef]
- Dooms-Goossens, A.; Buyse, L.; Stals, H. Maleated soybean oil, a new cosmetic allergen. Contact Dermat. 1995, 32, 49–51. [Google Scholar] [CrossRef] [PubMed]
- Le Coz, C.J.; Lefèbvre, C. Contact dermatitis from maleated soybean oil: Last gasps of an expiring cosmetic allergen. Contact Dermat. 2000, 43, 118–119. [Google Scholar]
- Kim, J.N.; Han, S.N.; Ha, T.J.; Kim, H.-K. Black soybean anthocyanins attenuate inflammatory responses by suppressing reactive oxygen species production and mitogen activated protein kinases signaling in lipopolysaccharide-stimulated macrophages. Nutr. Res. Pract. 2017, 11, 357–364. [Google Scholar] [CrossRef] [PubMed]
- Omoni, A.O.; Aluko, R.E. Soybean Foods and Their Benefits: Potential Mechanisms of Action. Nutr. Rev. 2005, 63, 272–283. [Google Scholar] [CrossRef]
- Hillman, G.G. Soy Isoflavones Protect Normal Tissues While Enhancing Radiation Responses. Semin. Radiat. Oncol. 2019, 29, 62–71. [Google Scholar] [CrossRef]
- Rizzo, G. The Antioxidant Role of Soy and Soy Foods in Human Health. Antioxidants 2020, 9, 635. [Google Scholar] [CrossRef]
- Jung, A.R.; Ahn, S.-h.; Park, I.-S.; Park, S.-Y.; Jeong, S.-I.; Cheon, J.-H.; Kim, K. Douchi (fermented Glycine max Merr.) alleviates atopic dermatitis-like skin lesions in NC/Nga mice by regulation of PKC and IL-4. BMC Complement. Altern. Med. 2016, 16, 416. [Google Scholar] [CrossRef]
- Cheong, K.L.; Qiu, H.M.; Du, H.; Liu, Y.; Khan, B.M. Oligosaccharides Derived from Red Seaweed: Production, Properties, and Potential Health and Cosmetic Applications. Molecules 2018, 23, 2451. [Google Scholar] [CrossRef]
- Kobayashi, R.; Takisada, M.; Suzuki, T.; Kirimura, K.; Usami, S. Neoagarobiose as a novel moisturizer with whitening effect. Biosci. Biotechnol. Biochem. 1997, 61, 162–163. [Google Scholar] [CrossRef]
- Kanlayavattanakul, M.; Lourith, N. Biopolysaccharides for skin hydrating cosmetics. In Polysaccharides; Springer International Publishing: Berlin/Heidelberg, Germany, 2015; pp. 1867–1892. [Google Scholar] [CrossRef]
- Dorjsembe, B.; Nho, C.W.; Choi, Y.; Kim, J.C. Extract from Black Soybean Cultivar A63 Extract Ameliorates Atopic Dermatitis-like Skin Inflammation in an Oxazolone-Induced Murine Model. Molecules 2022, 27, 2751. [Google Scholar] [CrossRef]
- Jimenez-Garcia, C.; Perula-de Torres, L.A.; Villegas-Becerril, E.; Muñoz-Gavilan, J.J.; Espinosa-Calvo, M.; Montes-Redondo, G.; Romero-Rodriguez, E.; Manzanaro, M.C.M.; Santiago, F.G.; Serrano, C.B.; et al. Efficacy of an aloe vera, chamomile, and thyme cosmetic cream for the prophylaxis and treatment of mild dermatitis induced by radiation therapy in breast cancer patients: A controlled clinical trial (Alantel Trials). Trials 2024, 25, 84. [Google Scholar] [CrossRef] [PubMed]
- Huang, M.-Y.; Huang, J.-J.; Chai, C.-Y.; Chen, S.-H.; Kuo, M.-P.; Lin, C.-C. The Reduction Effect of Extracts of Soybean Seeds on Acute Radiation Dermatitis. Fooyin J. Health Sci. 2010, 2, 21–25. [Google Scholar] [CrossRef]
- Chan, R.J.; Larsen, E.; Chan, P. Re-examining the Evidence in Radiation Dermatitis Management Literature: An Overview and a Critical Appraisal of Systematic Reviews. Int. J. Radiat. Oncol. Biol. Phys. 2012, 84, e357–e362. [Google Scholar] [CrossRef]
- Finkelstein, S.; Kanee, L.; Behroozian, T.; Wolf, J.R.; van den Hurk, C.; Chow, E.; Bonomo, P. Comparison of clinical practice guidelines on radiation dermatitis: A narrative review. Support Care Cancer 2022, 30, 4663–4674. [Google Scholar] [CrossRef]
- Wickline, M.M. Prevention and treatment of acute radiation dermatitis: A literature review. Oncol. Nurs. Forum 2007, 31, 237–247. [Google Scholar] [CrossRef]
- Ryan Wolf, J.; Gewandter, J.S.; Bautista, J.; Heckler, C.E.; Strasser, J.; Dyk, P.; Anderson, T.; Gross, H.; Speer, T.; Dolohanty, L.; et al. Utility of topical agents for radiation dermatitis and pain: A randomized clinical trial. Support. Care Cancer 2020, 28, 3303–3311. [Google Scholar] [CrossRef]
- Rezghi, M.; Farahani, A.M.; Asadi, F.; Mitra, S.; Dash, R.; Mozaffarpour, S.A.; Memariani, Z. Application of Natural Products in Radiotherapy-Induced Dermatitis: A Comprehensive Review. Tradit. Integr. Med. 2021, 6, 259–287. [Google Scholar] [CrossRef]
- Ferreira, E.B.; Ciol, M.A.; de Meneses, A.G.; Bontempo, P.d.S.M.; Hoffman, J.M.; dos Reis, P.E.D. Chamomile Gel versus Urea Cream to Prevent Acute Radiation Dermatitis in Head and Neck Cancer Patients: Results from a Preliminary Clinical Trial. Integr. Cancer Ther. 2020, 19, 1534735420962174. [Google Scholar] [CrossRef]
- Haddad, P.; Amouzgar-Hashemi, F.; Samsami, S.; Chinichian, S.; Oghabian, M.A. Aloe vera for prevention of radiation-induced dermatitis: A self-controlled clinical trial. Curr. Oncol. 2013, 20, e345–e348. [Google Scholar] [CrossRef]
- Koukourakis, G.; Pissakas, G.; Ganos, C.G.; Sivolapenko, G.; Kardamakis, D. Effectiveness and Tolerability of Natural Herbal Formulations in the Prevention of Radiation-Induced Skin Toxicity in Patients Undergoing Radiotherapy. Int. J. Low. Extrem. Wounds 2022, 21, 75–86. [Google Scholar] [CrossRef]
- Matceyevsky, D.; Hahoshen, N.Y.; Vexler, A.; Noam, A.; Khafif, A.; Ben-Yosef, R. Assessing the effectiveness of Dead Sea products as prophylactic agents for acute radiochemotherapy-induced skin and mucosal toxicity in patients with head and neck cancers: A phase 2 study. Isr. Med. Assoc. J. 2007, 9, 439–442. [Google Scholar] [PubMed]
- Olsen, D.L.; Raub, W.; Bradley, C.; Johnson, M.; Macias, J.L.; Love, V.; Markoe, A. The effect of aloe vera gel/mild soap versus mild soap alone in preventing skin reactions in patients undergoing radiation therapy. Oncol. Nurs. Forum 2001, 28, 543–547. [Google Scholar] [PubMed]
- Palatty, P.L.; Azmidah, A.; Rao, S.; Jayachander, D.; Thilakchand, K.R.; Rai, M.P.; Haniadka, R.; Simon, P.; Ravi, R.; Jimmy, R.; et al. Topical application of a sandal wood oil and turmeric based cream prevents radiodermatitis in head and neck cancer patients undergoing external beam radiotherapy: A pilot study. Br. J. Radiol. 2014, 87, 20130490. [Google Scholar] [CrossRef] [PubMed]
- Rao, S.; Hegde, S.K.; Baliga-Rao, M.P.; Palatty, P.L.; George, T.; Baliga, M.S. An Aloe Vera-Based Cosmeceutical Cream Delays and Mitigates Ionizing Radiation-Induced Dermatitis in Head and Neck Cancer Patients Undergoing Curative Radiotherapy: A Clinical Study. Medicines 2017, 4, 44. [Google Scholar] [CrossRef]
- Ferreira, E.B.; Vasques, C.I.; Gadia, R.; Chan, R.J.; Guerra, E.N.S.; Mezzomo, L.A.; De Luca Canto, G.; dos Reis, P.E.D. Topical interventions to prevent acute radiation dermatitis in head and neck cancer patients: A systematic review. Support. Care Cancer 2017, 25, 1001–1011. [Google Scholar] [CrossRef]
- Haruna, F.; Lipsett, A.; Marignol, L. Topical Management of Acute Radiation Dermatitis in Breast Cancer Patients: A Systematic Review and Meta-Analysis. Anticancer Res. 2017, 37, 5343–5353. [Google Scholar]
- Zenda, S.; Yamaguchi, T.; Yokota, T.; Miyaji, T.; Mashiko, T.; Tanaka, M.; Yonemura, M.; Takeno, M.; Okano, T.; Kawasaki, T.; et al. Topical steroid versus placebo for the prevention of radiation dermatitis in head and neck cancer patients receiving chemoradiotherapy: The study protocol of J-SUPPORT 1602 (TOPICS study), a randomized double-blinded phase 3 trial. BMC Cancer 2018, 18, 873. [Google Scholar] [CrossRef]
- Nagano, T.; Wu, W.; Tsumura, K.; Yonemoto-Yano, H.; Kamada, T.; Haruma, K. The inhibitory effect of soybean and soybean isoflavone diets on 2,4-dinitrofluorobenzene-induced contact hypersensitivity in mice. Biosci. Biotechnol. Biochem. 2016, 80, 991–997. [Google Scholar] [CrossRef]
- Nagano, T.; Katase, M.; Tsumura, K. Impact of soymilk consumption on 2,4-dinitrofluorobenzene-induced contact hypersensitivity and gut microbiota in mice. Int. J. Food Sci. Nutr. 2019, 70, 579–584. [Google Scholar] [CrossRef]
- Nagano, T.; Katase, M.; Tsumura, K. Inhibitory effects of dietary soy isoflavone and gut microbiota on contact hypersensitivity in mice. Food Chem. 2019, 272, 33–38. [Google Scholar] [CrossRef]
- Li, M.; Qian, M.; Jiang, Q.; Tan, B.; Yin, Y.; Han, X. Evidence of Flavonoids on Disease Prevention. Antioxidants 2023, 12, 527. [Google Scholar] [CrossRef] [PubMed]
- Xu, J.; Yang, G.; An, W.; Wang, W.; Li, F.; Meng, Y.; Wang, X. Correlations between the severity of radiation-induced oral mucositis and salivary epidermal growth factor as well as inflammatory cytokines in patients with head and neck cancer. Head Neck 2023, 45, 1122–1129. [Google Scholar] [CrossRef] [PubMed]
- Su, L.; Wang, Z.; Huang, F.; Lan, R.; Chen, X.; Han, D.; Zhang, L.; Zhang, W.; Hong, J. 18β-Glycyrrhetinic acid mitigates radiation-induced skin damage via NADPH oxidase/ROS/p38MAPK and NF-κB pathways. Environ. Toxicol. Pharmacol. 2018, 60, 82–90. [Google Scholar] [CrossRef] [PubMed]
- Waga, K.; Yamaguchi, M.; Miura, S.; Nishida, T.; Itai, A.; Nakanishi, R.; Kashiwakura, I. IKKβ Inhibitor IMD-0354 Attenuates Radiation Damage in Whole-body X-Irradiated Mice. Oxidative Med. Cell. Longev. 2019, 2019, 5340290. [Google Scholar] [CrossRef] [PubMed]
- Keller, M.; Manzocchi, E.; Rentsch, D.; Lugarà, R.; Giller, K. Antioxidant and Inflammatory Gene Expression Profiles of Bovine Peripheral Blood Mononuclear Cells in Response to Arthrospira platensis before and after LPS Challenge. Antioxidants 2021, 10, 814. [Google Scholar] [CrossRef]
- Burnett, C.L.; Bergfeld, W.F.; Belsito, D.V.; Hill, R.A.; Klaassen, C.D.; Liebler, D.C.; Marks, J.G.; Shank, R.C.; Slaga, T.J.; Snyder, P.W.; et al. Safety Assessment of Soy Proteins and Peptides as Used in Cosmetics. Int. J. Toxicol. 2023, 42, 102s–113s. [Google Scholar] [CrossRef]
- Rzepecki, A.K.; Murase, J.E.; Juran, R.; Fabi, S.G.; McLellan, B.N. Estrogen-deficient skin: The role of topical therapy. Int. J. Womens Dermatol. 2019, 5, 85–90. [Google Scholar] [CrossRef]
- Hampton, A.L.; Hish, G.A.; Aslam, M.N.; Rothman, E.D.; Bergin, I.L.; Patterson, K.A.; Naik, M.; Paruchuri, T.; Varani, J.; Rush, H.G. Progression of Ulcerative Dermatitis Lesions in C57BL/6Crl Mice and the Development of a Scoring System for Dermatitis Lesions. J. Am. Assoc. Lab. Anim. Sci. 2012, 51, 586–593. [Google Scholar]
Score | A. Scratch Number | B. Characteristics of Lesions | C. Lesion Length |
---|---|---|---|
0 | None | No lesion present | 0 cm |
1 | <5 | Excoriation only one, small punctuate crust | <1 cm |
2 | 5–10 | Multiple, small punctuate crusts or coalescing crust | 1–2 cm |
3 | >10 | Erosion or ulceration | >2 cm |
Calculated score: [(A + B + C)/9] × 100 |
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. |
© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Share and Cite
Lee, H.-H.; Huang, Y.-H.; Huang, J.-J.; Huang, M.-Y. Exploring Black Soybean Extract Cream for Inflammatory Dermatitis—Toward Radiation Dermatitis Relief. Int. J. Mol. Sci. 2024, 25, 11598. https://doi.org/10.3390/ijms252111598
Lee H-H, Huang Y-H, Huang J-J, Huang M-Y. Exploring Black Soybean Extract Cream for Inflammatory Dermatitis—Toward Radiation Dermatitis Relief. International Journal of Molecular Sciences. 2024; 25(21):11598. https://doi.org/10.3390/ijms252111598
Chicago/Turabian StyleLee, Hsin-Hua, Yu-Hsiang Huang, Joh-Jong Huang, and Ming-Yii Huang. 2024. "Exploring Black Soybean Extract Cream for Inflammatory Dermatitis—Toward Radiation Dermatitis Relief" International Journal of Molecular Sciences 25, no. 21: 11598. https://doi.org/10.3390/ijms252111598
APA StyleLee, H.-H., Huang, Y.-H., Huang, J.-J., & Huang, M.-Y. (2024). Exploring Black Soybean Extract Cream for Inflammatory Dermatitis—Toward Radiation Dermatitis Relief. International Journal of Molecular Sciences, 25(21), 11598. https://doi.org/10.3390/ijms252111598