Next Article in Journal
Proteomic Profiling of Saliva and Tears in Radiated Head and Neck Cancer Patients as Compared to Primary Sjögren’s Syndrome Patients
Next Article in Special Issue
Store-Operated Ca2+ Entry in Skeletal Muscle Contributes to the Increase in Body Temperature during Exertional Stress
Previous Article in Journal
Biomarkers of Glucose Metabolism Alterations and the Onset of Metabolic Syndrome in Survivors of Childhood Acute Lymphoblastic Leukemia
Previous Article in Special Issue
The Role of Glycogen Synthase Kinase-3 in the Regulation of Ribosome Biogenesis in Rat Soleus Muscle under Disuse Conditions
 
 
Article

A Single Bout of Ultra-Endurance Exercise Reveals Early Signs of Muscle Aging in Master Athletes

1
Université Clermont Auvergne, INRAE, UNH, Unité de Nutrition Humaine, CRNH Auvergne, F-63000 Clermont-Ferrand, France
2
Université Clermont Auvergne, INRAE, Metabolomic and Proteomic Exploration Facility, F-63000 Clermont-Ferrand, France
3
Université de Lyon, UJM-Saint-Etienne, Inter-University Laboratory of Human Movement Biology, EA 7424, F-42023 Saint-Etienne, France
*
Author to whom correspondence should be addressed.
Academic Editor: Rasmus Kjøbsted
Int. J. Mol. Sci. 2022, 23(7), 3713; https://doi.org/10.3390/ijms23073713
Received: 11 February 2022 / Revised: 22 March 2022 / Accepted: 26 March 2022 / Published: 28 March 2022
(This article belongs to the Special Issue Advances in Skeletal Muscle Function and Metabolism)
Middle-aged and master endurance athletes exhibit similar physical performance and long-term muscle adaptation to aerobic exercise. Nevertheless, we hypothesized that the short-term plasticity of the skeletal muscle might be distinctly altered for master athletes when they are challenged by a single bout of prolonged moderate-intensity exercise. Six middle-aged (37Y) and five older (50Y) master highly-trained athletes performed a 24-h treadmill run (24TR). Vastus lateralis muscle biopsies were collected before and after the run and assessed for proteomics, fiber morphometry, intramyocellular lipid droplets (LD), mitochondrial oxidative activity, extracellular matrix (ECM), and micro-vascularisation. Before 24TR, muscle fiber type morphometry, intramyocellular LD, oxidative activity, ECM and micro-vascularisation were similar between master and middle-aged runners. For 37Y runners, 24TR was associated with ECM thickening, increased capillary-to-fiber interface, and an 89% depletion of LD in type-I fibers. In contrast, for 50Y runners, 24TR did not alter ECM and capillarization and poorly depleted LDs. Moreover, an impaired succinate dehydrogenase activity and functional class scoring of proteomes suggested reduced oxidative phosphorylation post-24TR exclusively in 50Y muscle. Collectively, our data support that middle-aged and master endurance athletes exhibit distinct transient plasticity in response to a single bout of ultra-endurance exercise, which may constitute early signs of muscle aging for master athletes. View Full-Text
Keywords: aging; exercise; skeletal muscle; capillaries; lipid droplets; extracellular matrix aging; exercise; skeletal muscle; capillaries; lipid droplets; extracellular matrix
Show Figures

Figure 1

MDPI and ACS Style

Coudy-Gandilhon, C.; Gueugneau, M.; Chambon, C.; Taillandier, D.; Combaret, L.; Polge, C.; Millet, G.Y.; Féasson, L.; Béchet, D. A Single Bout of Ultra-Endurance Exercise Reveals Early Signs of Muscle Aging in Master Athletes. Int. J. Mol. Sci. 2022, 23, 3713. https://doi.org/10.3390/ijms23073713

AMA Style

Coudy-Gandilhon C, Gueugneau M, Chambon C, Taillandier D, Combaret L, Polge C, Millet GY, Féasson L, Béchet D. A Single Bout of Ultra-Endurance Exercise Reveals Early Signs of Muscle Aging in Master Athletes. International Journal of Molecular Sciences. 2022; 23(7):3713. https://doi.org/10.3390/ijms23073713

Chicago/Turabian Style

Coudy-Gandilhon, Cécile, Marine Gueugneau, Christophe Chambon, Daniel Taillandier, Lydie Combaret, Cécile Polge, Guillaume Y. Millet, Léonard Féasson, and Daniel Béchet. 2022. "A Single Bout of Ultra-Endurance Exercise Reveals Early Signs of Muscle Aging in Master Athletes" International Journal of Molecular Sciences 23, no. 7: 3713. https://doi.org/10.3390/ijms23073713

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop