Next Article in Journal
Ligandability Assessment of Human Glutathione Transferase M1-1 Using Pesticides as Chemical Probes
Next Article in Special Issue
Antimicrobial Efficacy and Permeability of Various Sealing Materials in Two Different Types of Implant–Abutment Connections
Previous Article in Journal
Industrially Relevant Enzyme Cascades for Drug Synthesis and Their Ecological Assessment
Previous Article in Special Issue
Detection of Human Neutrophil Elastase by Fluorescent Peptide Sensors Conjugated to TEMPO-Oxidized Nanofibrillated Cellulose
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 23
Issue 7
10.3390/ijms23073598
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Ascorbic Acid as an Adjuvant to Unbleached Cotton Promotes Antimicrobial Activity in Spunlace Nonwovens

by
Judson Vincent Edwards
1,*,
Nicolette T. Prevost
1,
Dorne Yager
2,
Robert Mackin
1,
Michael Santiago
1,
SeChin Chang
1,
Brian Condon
1 and
Joseph Dacorta
3
1
Southern Regional Research Center, Agricultural Research Service, United States Department of Agriculture, 1100 Robert E. Lee Blvd., New Orleans, LA 70124, USA
2
Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
3
H&H Medical, Williamsburg, VA 28135, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2022, 23(7), 3598; https://doi.org/10.3390/ijms23073598
Submission received: 12 October 2021 / Revised: 12 March 2022 / Accepted: 15 March 2022 / Published: 25 March 2022
(This article belongs to the Special Issue Materials for Infectious Diseases)
Browse Figures
Review Reports Versions Notes

Abstract

The development of affordable, effective, and environmentally friendly barrier fabrics is a current goal in antimicrobial textile development. The discovery of new routes to achieve non-toxic naturally occurring molecules with antimicrobial activity is of interest in the development of materials that promote wound healing, improve hygiene, and offer protection against nosocomial infection. Highly cleaned and sterile unbleached cotton has constituents that produce hydrogen peroxide at levels commensurate with those that favor cell signaling in wound healing. Here, we show the antimicrobial and antiviral properties of spunlaced griege cotton-containing nonwovens treated with ascorbic acid formulations. The mechanism of action occurs through the promotion of enhanced hydrogen peroxide activity. The levels of hydrogen peroxide activity afford antimicrobial activity against Gram-negative and Gram-positive bacteria and antiviral activity against MS2 bacteriophages. Spun-bond nonwoven unbleached cotton was treated with ascorbic acid using traditional pad-dry-cure methods. An assessment of antibacterial and antiviral activity against Staphylococcus aureus, Klebsiella pneumoniae, and MS2 bacteriophages with the AATCC 100 test method showed a 99.99% inhibitory activity. An approach to the covalent attachment of ascorbic to cellulose through citric acid crosslinking chemistry is also discussed. Thus, a simple, low-cost approach to antimicrobial and antiviral cotton-based nonwovens applicable to dressings, nosocomial barrier fabrics, and face masks can be adopted by combining ascorbic acid with spunlace greige cotton nonwoven fabrics.
Keywords: antimicrobial activity; ascorbic acid; cotton antimicrobial activity; ascorbic acid; cotton

Share and Cite

MDPI and ACS Style

Edwards, J.V.; Prevost, N.T.; Yager, D.; Mackin, R.; Santiago, M.; Chang, S.; Condon, B.; Dacorta, J. Ascorbic Acid as an Adjuvant to Unbleached Cotton Promotes Antimicrobial Activity in Spunlace Nonwovens. Int. J. Mol. Sci. 2022, 23, 3598. https://doi.org/10.3390/ijms23073598

AMA Style

Edwards JV, Prevost NT, Yager D, Mackin R, Santiago M, Chang S, Condon B, Dacorta J. Ascorbic Acid as an Adjuvant to Unbleached Cotton Promotes Antimicrobial Activity in Spunlace Nonwovens. International Journal of Molecular Sciences. 2022; 23(7):3598. https://doi.org/10.3390/ijms23073598

Chicago/Turabian Style

Edwards, Judson Vincent, Nicolette T. Prevost, Dorne Yager, Robert Mackin, Michael Santiago, SeChin Chang, Brian Condon, and Joseph Dacorta. 2022. "Ascorbic Acid as an Adjuvant to Unbleached Cotton Promotes Antimicrobial Activity in Spunlace Nonwovens" International Journal of Molecular Sciences 23, no. 7: 3598. https://doi.org/10.3390/ijms23073598

APA Style

Edwards, J. V., Prevost, N. T., Yager, D., Mackin, R., Santiago, M., Chang, S., Condon, B., & Dacorta, J. (2022). Ascorbic Acid as an Adjuvant to Unbleached Cotton Promotes Antimicrobial Activity in Spunlace Nonwovens. International Journal of Molecular Sciences, 23(7), 3598. https://doi.org/10.3390/ijms23073598

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop