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Article

Hybrid Nanoparticles and Composite Hydrogel Systems for Delivery of Peptide Antibiotics

1
Institute of Macromolecular Compounds, Russian Academy of Sciences, Bolshoi VO 31, 199004 St. Petersburg, Russia
2
Institute of Chemistry, St. Petersburg State University, Universitetskii 26, Peterhof, 198504 St. Petersburg, Russia
3
State Research Institute of Highly Pure Biopreparations, Pudozhsakya 7, 197110 St. Petersburg, Russia
4
Institute of Technical Chemistry, Gottfried-Wilhelm-Leibniz University of Hannover, 30167 Hannover, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Maurizio Battino
Int. J. Mol. Sci. 2022, 23(5), 2771; https://doi.org/10.3390/ijms23052771
Received: 31 January 2022 / Revised: 24 February 2022 / Accepted: 28 February 2022 / Published: 2 March 2022
(This article belongs to the Special Issue Biopolymers in Drug and Gene Delivery Systems)
The growing number of drug-resistant pathogenic bacteria poses a global threat to human health. For this reason, the search for ways to enhance the antibacterial activity of existing antibiotics is now an urgent medical task. The aim of this study was to develop novel delivery systems for polymyxins to improve their antimicrobial properties against various infections. For this, hybrid core–shell nanoparticles, consisting of silver core and a poly(glutamic acid) shell capable of polymyxin binding, were developed and carefully investigated. Characterization of the hybrid nanoparticles revealed a hydrodynamic diameter of approximately 100 nm and a negative electrokinetic potential. The nanoparticles demonstrated a lack of cytotoxicity, a low uptake by macrophages, and their own antimicrobial activity. Drug loading and loading efficacy were determined for both polymyxin B and E, and the maximal loaded value with an appropriate size of the delivery systems was 450 µg/mg of nanoparticles. Composite materials based on agarose hydrogel were prepared, containing both the loaded hybrid systems and free antibiotics. The features of polymyxin release from the hybrid nanoparticles and the composite materials were studied, and the mechanisms of release were analyzed using different theoretical models. The antibacterial activity against Pseudomonas aeruginosa was evaluated for both the polymyxin hybrid and the composite delivery systems. All tested samples inhibited bacterial growth. The minimal inhibitory concentrations of the polymyxin B hybrid delivery system demonstrated a synergistic effect when compared with either the antibiotic or the silver nanoparticles alone. View Full-Text
Keywords: hybrid nanoparticles; core–shell structures; peptides; polymyxin; colistin; drug delivery systems; antibiotics; antimicrobial properties; composite materials hybrid nanoparticles; core–shell structures; peptides; polymyxin; colistin; drug delivery systems; antibiotics; antimicrobial properties; composite materials
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MDPI and ACS Style

Iudin, D.; Vasilieva, M.; Knyazeva, E.; Korzhikov-Vlakh, V.; Demyanova, E.; Lavrentieva, A.; Skorik, Y.; Korzhikova-Vlakh, E. Hybrid Nanoparticles and Composite Hydrogel Systems for Delivery of Peptide Antibiotics. Int. J. Mol. Sci. 2022, 23, 2771. https://doi.org/10.3390/ijms23052771

AMA Style

Iudin D, Vasilieva M, Knyazeva E, Korzhikov-Vlakh V, Demyanova E, Lavrentieva A, Skorik Y, Korzhikova-Vlakh E. Hybrid Nanoparticles and Composite Hydrogel Systems for Delivery of Peptide Antibiotics. International Journal of Molecular Sciences. 2022; 23(5):2771. https://doi.org/10.3390/ijms23052771

Chicago/Turabian Style

Iudin, Dmitrii, Marina Vasilieva, Elena Knyazeva, Viktor Korzhikov-Vlakh, Elena Demyanova, Antonina Lavrentieva, Yury Skorik, and Evgenia Korzhikova-Vlakh. 2022. "Hybrid Nanoparticles and Composite Hydrogel Systems for Delivery of Peptide Antibiotics" International Journal of Molecular Sciences 23, no. 5: 2771. https://doi.org/10.3390/ijms23052771

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