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Review

Signaling Mechanisms and Pharmacological Modulators Governing Diverse Aquaporin Functions in Human Health and Disease

1
School of Biomedicine, University of Adelaide, Adelaide, SA 5005, Australia
2
College of Health and Life Sciences, Aston University, Birmingham B4 7ET, UK
3
Department of Physiology Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK
4
Oxford Parkinson’s Disease Centre, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Antonio Ferrer-Montiel and Antonio Felipe
Int. J. Mol. Sci. 2022, 23(3), 1388; https://doi.org/10.3390/ijms23031388
Received: 14 December 2021 / Revised: 18 January 2022 / Accepted: 20 January 2022 / Published: 26 January 2022
(This article belongs to the Special Issue Membrane Channels in Physiology and Pathology)
The aquaporins (AQPs) are a family of small integral membrane proteins that facilitate the bidirectional transport of water across biological membranes in response to osmotic pressure gradients as well as enable the transmembrane diffusion of small neutral solutes (such as urea, glycerol, and hydrogen peroxide) and ions. AQPs are expressed throughout the human body. Here, we review their key roles in fluid homeostasis, glandular secretions, signal transduction and sensation, barrier function, immunity and inflammation, cell migration, and angiogenesis. Evidence from a wide variety of studies now supports a view of the functions of AQPs being much more complex than simply mediating the passive flow of water across biological membranes. The discovery and development of small-molecule AQP inhibitors for research use and therapeutic development will lead to new insights into the basic biology of and novel treatments for the wide range of AQP-associated disorders. View Full-Text
Keywords: aquaporin (AQP); membranes; water; fluid; secretion; osmosis; facilitated diffusion; signaling aquaporin (AQP); membranes; water; fluid; secretion; osmosis; facilitated diffusion; signaling
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MDPI and ACS Style

Wagner, K.; Unger, L.; Salman, M.M.; Kitchen, P.; Bill, R.M.; Yool, A.J. Signaling Mechanisms and Pharmacological Modulators Governing Diverse Aquaporin Functions in Human Health and Disease. Int. J. Mol. Sci. 2022, 23, 1388. https://doi.org/10.3390/ijms23031388

AMA Style

Wagner K, Unger L, Salman MM, Kitchen P, Bill RM, Yool AJ. Signaling Mechanisms and Pharmacological Modulators Governing Diverse Aquaporin Functions in Human Health and Disease. International Journal of Molecular Sciences. 2022; 23(3):1388. https://doi.org/10.3390/ijms23031388

Chicago/Turabian Style

Wagner, Kim, Lucas Unger, Mootaz M. Salman, Philip Kitchen, Roslyn M. Bill, and Andrea J. Yool. 2022. "Signaling Mechanisms and Pharmacological Modulators Governing Diverse Aquaporin Functions in Human Health and Disease" International Journal of Molecular Sciences 23, no. 3: 1388. https://doi.org/10.3390/ijms23031388

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