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Article

NX210c Peptide Promotes Glutamatergic Receptor-Mediated Synaptic Transmission and Signaling in the Mouse Central Nervous System

1
Axoltis Pharma, 60 Avenue Rockefeller, 69008 Lyon, France
2
Neuro-Sys, 410 Chemin Départemental 60, 13120 Gardanne, France
3
E-Phy-Science, Bioparc, 2400 Routes de Colles, Sophia Antipolis, 06410 Biot, France
4
Godfrin Life-Sciences, 8 Impasse de la Source, 69300 Caluire-et-Cuire, France
*
Author to whom correspondence should be addressed.
Academic Editors: Hari Shanker Sharma and Elek Molnár
Int. J. Mol. Sci. 2022, 23(16), 8867; https://doi.org/10.3390/ijms23168867
Received: 28 June 2022 / Revised: 28 July 2022 / Accepted: 8 August 2022 / Published: 9 August 2022
NX210c is a disease-modifying dodecapeptide derived from the subcommissural organ-spondin that is under preclinical and clinical development for the treatment of neurological disorders. Here, using whole-cell patch-clamp recordings, we demonstrate that NX210c increased α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)- and GluN2A-containing N-methyl-D-aspartate receptor (GluN2A-NMDAR)-mediated excitatory postsynaptic currents in the brain. Accordingly, using extracellular field excitatory postsynaptic potential recordings, an enhancement of synaptic transmission was shown in the presence of NX210c in two different neuronal circuits. Furthermore, the modulation of synaptic transmission and GluN2A-NMDAR-driven signaling by NX210c restored memory in mice chronically treated with the NMDAR antagonist phencyclidine. Overall, by promoting glutamatergic receptor-related neurotransmission and signaling, NX210c represents an innovative therapeutic opportunity for patients suffering from CNS disorders, injuries, and states with crippling synaptic dysfunctions. View Full-Text
Keywords: AMPA receptor; NMDA receptor; GluN2A; synaptic transmission; NMDA receptor signaling; pCREB; drug candidate; cognition; brain AMPA receptor; NMDA receptor; GluN2A; synaptic transmission; NMDA receptor signaling; pCREB; drug candidate; cognition; brain
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MDPI and ACS Style

Lemarchant, S.; Sourioux, M.; Le Douce, J.; Henriques, A.; Callizot, N.; Hugues, S.; Farinelli, M.; Godfrin, Y. NX210c Peptide Promotes Glutamatergic Receptor-Mediated Synaptic Transmission and Signaling in the Mouse Central Nervous System. Int. J. Mol. Sci. 2022, 23, 8867. https://doi.org/10.3390/ijms23168867

AMA Style

Lemarchant S, Sourioux M, Le Douce J, Henriques A, Callizot N, Hugues S, Farinelli M, Godfrin Y. NX210c Peptide Promotes Glutamatergic Receptor-Mediated Synaptic Transmission and Signaling in the Mouse Central Nervous System. International Journal of Molecular Sciences. 2022; 23(16):8867. https://doi.org/10.3390/ijms23168867

Chicago/Turabian Style

Lemarchant, Sighild, Mélissa Sourioux, Juliette Le Douce, Alexandre Henriques, Noëlle Callizot, Sandrine Hugues, Mélissa Farinelli, and Yann Godfrin. 2022. "NX210c Peptide Promotes Glutamatergic Receptor-Mediated Synaptic Transmission and Signaling in the Mouse Central Nervous System" International Journal of Molecular Sciences 23, no. 16: 8867. https://doi.org/10.3390/ijms23168867

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