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Article

The Anticancer Activity Conferred by the Mud Crab Antimicrobial Peptide Scyreprocin through Apoptosis and Membrane Disruption

by 1, 1,2,3, 1,2,3 and 1,2,3,*
1
State Key Laboratory of Marine Environmental Science, College of Ocean and Earth Sciences, Xiamen University, Xiamen 361102, China
2
State-Province Joint Engineering Laboratory of Marine Bioproducts and Technology, College of Ocean and Earth Sciences, Xiamen University, Xiamen 361102, China
3
Fujian Innovation Research Institute for Marine Biological Antimicrobial Peptide Industrial Technology, College of Ocean & Earth Sciences, Xiamen University, Xiamen 361102, China
*
Author to whom correspondence should be addressed.
Academic Editor: Giovanna Batoni
Int. J. Mol. Sci. 2022, 23(10), 5500; https://doi.org/10.3390/ijms23105500
Received: 17 April 2022 / Revised: 4 May 2022 / Accepted: 11 May 2022 / Published: 14 May 2022
Scyreprocin is an antimicrobial peptide first identified in the mud crab Scylla paramamosain. Herein, we showed that its recombinant product (rScyreprocin) could significantly inhibit the growth of human lung cancer NCI-H460 cells (H460), but showed no cytotoxicity to human lung fibroblasts (HFL1). rScyreprocin was a membrane-active peptide that firstly induced the generation of reactive oxygen species (ROS) in H460, and led to endoplasmic reticulum stress and Ca2+ release, which resulted in mitochondrial dysfunction and subsequently activation of caspase-3 cascades, and ultimately led to apoptosis. The comprehensive results indicated that rScyreprocin exerted anticancer activity by disrupting cell membrane and inducing apoptosis. The in vivo efficacy test demonstrated that intratumoral injection of rScyreprocin significantly inhibited the growth of H460 xenografts, which was close to that of the cisplatin (inhibition rate: 69.94% vs. 80.76%). Therefore, rScyreprocin is expected to become a promising candidate for the treatment of lung cancer. View Full-Text
Keywords: scyreprocin; antimicrobial peptide; apoptosis; anti-tumor; non-small-cell lung cancer scyreprocin; antimicrobial peptide; apoptosis; anti-tumor; non-small-cell lung cancer
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MDPI and ACS Style

Yang, Y.; Chen, H.-Y.; Hao, H.; Wang, K.-J. The Anticancer Activity Conferred by the Mud Crab Antimicrobial Peptide Scyreprocin through Apoptosis and Membrane Disruption. Int. J. Mol. Sci. 2022, 23, 5500. https://doi.org/10.3390/ijms23105500

AMA Style

Yang Y, Chen H-Y, Hao H, Wang K-J. The Anticancer Activity Conferred by the Mud Crab Antimicrobial Peptide Scyreprocin through Apoptosis and Membrane Disruption. International Journal of Molecular Sciences. 2022; 23(10):5500. https://doi.org/10.3390/ijms23105500

Chicago/Turabian Style

Yang, Ying, Hui-Yun Chen, Hua Hao, and Ke-Jian Wang. 2022. "The Anticancer Activity Conferred by the Mud Crab Antimicrobial Peptide Scyreprocin through Apoptosis and Membrane Disruption" International Journal of Molecular Sciences 23, no. 10: 5500. https://doi.org/10.3390/ijms23105500

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