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Review

Role of miRNAs in Human T Cell Leukemia Virus Type 1 Induced T Cell Leukemia: A Literature Review and Bioinformatics Approach

1
Department of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, Brazil
2
Unichristus University Center, Faculty of Biomedicine, Fortaleza 60430-275, CE, Brazil
3
Hematology and Transfusion Medicine Center, University of Campinas, Campinas 13083-970, SP, Brazil
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Department of Biological Sciences, Oncology Research Center, Federal University of Pará, Belém 66073-005, PA, Brazil
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Department of Hematology, Fortaleza General Hospital (HGF), Fortaleza 60150-160, CE, Brazil
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Department of Hematology, César Cals General Hospital, Fortaleza 60015-152, CE, Brazil
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Department of Health Sciences, Northeast Biotechnology Network (RENORBIO), Itaperi Campus, Ceará State University, Fortaleza 60740-903, CE, Brazil
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Yong Sun Lee and Alessandro Fatica
Int. J. Mol. Sci. 2022, 23(10), 5486; https://doi.org/10.3390/ijms23105486
Received: 10 April 2022 / Revised: 10 May 2022 / Accepted: 11 May 2022 / Published: 14 May 2022
(This article belongs to the Special Issue Non-coding RNAs in Pathogens and Associated Diseases)
Human T cell leukemia virus type 1 (HTLV-1) was identified as the first pathogenic human retrovirus and is estimated to infect 5 to 10 million individuals worldwide. Unlike other retroviruses, there is no effective therapy to prevent the onset of the most alarming diseases caused by HTLV-1, and the more severe cases manifest as the malignant phenotype of adult T cell leukemia (ATL). MicroRNA (miRNA) dysfunction is a common feature of leukemogenesis, and it is no different in ATL cases. Therefore, we sought to analyze studies that reported deregulated miRNA expression in HTLV-1 infected cells and patients’ samples to understand how this deregulation could induce malignancy. Through in silico analysis, we identified 12 miRNAs that stood out in the prediction of targets, and we performed functional annotation of the genes linked to these 12 miRNAs that appeared to have a major biological interaction. A total of 90 genes were enriched in 14 KEGG pathways with significant values, including TP53, WNT, MAPK, TGF-β, and Ras signaling pathways. These miRNAs and gene interactions are discussed in further detail for elucidation of how they may act as probable drivers for ATL onset, and while our data provide solid starting points for comprehension of miRNAs’ roles in HTLV-1 infection, continuous effort in oncologic research is still needed to improve our understanding of HTLV-1 induced leukemia. View Full-Text
Keywords: HTLV-1; T cell leukemia; miRNAs; carcinogenesis HTLV-1; T cell leukemia; miRNAs; carcinogenesis
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MDPI and ACS Style

Machado, C.B.; da Cunha, L.S.; Maués, J.H.d.S.; Pessoa, F.M.C.d.P.; de Oliveira, M.B.; Ribeiro, R.M.; Lopes, G.S.; de Moraes Filho, M.O.; de Moraes, M.E.A.; Khayat, A.S.; Moreira-Nunes, C.A. Role of miRNAs in Human T Cell Leukemia Virus Type 1 Induced T Cell Leukemia: A Literature Review and Bioinformatics Approach. Int. J. Mol. Sci. 2022, 23, 5486. https://doi.org/10.3390/ijms23105486

AMA Style

Machado CB, da Cunha LS, Maués JHdS, Pessoa FMCdP, de Oliveira MB, Ribeiro RM, Lopes GS, de Moraes Filho MO, de Moraes MEA, Khayat AS, Moreira-Nunes CA. Role of miRNAs in Human T Cell Leukemia Virus Type 1 Induced T Cell Leukemia: A Literature Review and Bioinformatics Approach. International Journal of Molecular Sciences. 2022; 23(10):5486. https://doi.org/10.3390/ijms23105486

Chicago/Turabian Style

Machado, Caio B., Leidivan S. da Cunha, Jersey H.d.S. Maués, Flávia M.C.d.P. Pessoa, Marcelo B. de Oliveira, Rodrigo M. Ribeiro, Germison S. Lopes, Manoel O. de Moraes Filho, Maria E.A. de Moraes, André S. Khayat, and Caroline A. Moreira-Nunes. 2022. "Role of miRNAs in Human T Cell Leukemia Virus Type 1 Induced T Cell Leukemia: A Literature Review and Bioinformatics Approach" International Journal of Molecular Sciences 23, no. 10: 5486. https://doi.org/10.3390/ijms23105486

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