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The Regulation of Collagen Processing by miRNAs in Disease and Possible Implications for Bone Turnover

1
Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, 60-781 Poznan, Poland
2
Department of Genetics, Wroclaw Medical University, 50-368 Wroclaw, Poland
3
Institute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland
4
Department of Paediatric Orthopaedics and Traumatology, Poznan University of Medical Sciences, 61-545 Poznan, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Alberto Falchetti
Int. J. Mol. Sci. 2022, 23(1), 91; https://doi.org/10.3390/ijms23010091
Received: 5 November 2021 / Revised: 20 December 2021 / Accepted: 21 December 2021 / Published: 22 December 2021
(This article belongs to the Special Issue Epigenetic Mechanisms and Human Pathology 2.0)
This article describes several recent examples of miRNA governing the regulation of the gene expression involved in bone matrix construction. We present the impact of miRNA on the subsequent steps in the formation of collagen type I. Collagen type I is a main factor of mechanical bone stiffness because it constitutes 90–95% of the organic components of the bone. Therefore, the precise epigenetic regulation of collagen formation may have a significant influence on bone structure. We also describe miRNA involvement in the expression of genes, the protein products of which participate in collagen maturation in various tissues and cancer cells. We show how non-collagenous proteins in the extracellular matrix are epigenetically regulated by miRNA in bone and other tissues. We also delineate collagen mineralisation in bones by factors that depend on miRNA molecules. This review reveals the tissue variability of miRNA regulation at different levels of collagen maturation and mineralisation. The functionality of collagen mRNA regulation by miRNA, as proven in other tissues, has not yet been shown in osteoblasts. Several collagen-regulating miRNAs are co-expressed with collagen in bone. We suggest that collagen mRNA regulation by miRNA could also be potentially important in bone metabolism. View Full-Text
Keywords: miRNA; extracellular matrix; collagen type I; bone turnover; non-collagenous proteins miRNA; extracellular matrix; collagen type I; bone turnover; non-collagenous proteins
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MDPI and ACS Style

Lehmann, T.P.; Guderska, U.; Kałek, K.; Marzec, M.; Urbanek, A.; Czernikiewicz, A.; Sąsiadek, M.; Karpiński, P.; Pławski, A.; Głowacki, M.; Jagodziński, P.P. The Regulation of Collagen Processing by miRNAs in Disease and Possible Implications for Bone Turnover. Int. J. Mol. Sci. 2022, 23, 91. https://doi.org/10.3390/ijms23010091

AMA Style

Lehmann TP, Guderska U, Kałek K, Marzec M, Urbanek A, Czernikiewicz A, Sąsiadek M, Karpiński P, Pławski A, Głowacki M, Jagodziński PP. The Regulation of Collagen Processing by miRNAs in Disease and Possible Implications for Bone Turnover. International Journal of Molecular Sciences. 2022; 23(1):91. https://doi.org/10.3390/ijms23010091

Chicago/Turabian Style

Lehmann, Tomasz P., Urszula Guderska, Klaudia Kałek, Maria Marzec, Agnieszka Urbanek, Alicja Czernikiewicz, Maria Sąsiadek, Paweł Karpiński, Andrzej Pławski, Maciej Głowacki, and Paweł P. Jagodziński. 2022. "The Regulation of Collagen Processing by miRNAs in Disease and Possible Implications for Bone Turnover" International Journal of Molecular Sciences 23, no. 1: 91. https://doi.org/10.3390/ijms23010091

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