Next Article in Journal
The Causes and Potential Injurious Effects of Elevated Serum Leptin Levels in Chronic Kidney Disease Patients
Next Article in Special Issue
Microglia–Neuron Crosstalk in Obesity: Melodious Interaction or Kiss of Death?
Previous Article in Journal
Exosomal Vimentin from Adipocyte Progenitors Protects Fibroblasts against Osmotic Stress and Inhibits Apoptosis to Enhance Wound Healing
Previous Article in Special Issue
Angiopoietin-Like Growth Factor Involved in Leptin Signaling in the Hypothalamus
Article

Effects of Overexpression of Neurosecretory Protein GL-Precursor Gene on Glucose Homeostasis and Insulin Sensitivity in Mice

Laboratory of Neurometabolism, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Hiroshima 739-8521, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Rosalía Rodríguez-Rodríguez
Int. J. Mol. Sci. 2021, 22(9), 4681; https://doi.org/10.3390/ijms22094681
Received: 27 March 2021 / Revised: 24 April 2021 / Accepted: 26 April 2021 / Published: 28 April 2021
(This article belongs to the Special Issue Hypothalamic Regulation of Obesity)
A high-fat diet (HFD) quickly induces obesity with insulin resistance and hyperglycemia. We previously reported that a novel hypothalamic small protein, named neurosecretory protein GL (NPGL), stimulates feeding and fat accumulation in mice. However, the effects of NPGL on insulin sensitivity and glucose homeostasis remain unknown. Hence, we subjected NPGL-precursor gene (Npgl)-overexpressing mice to the oral glucose tolerance test (OGTT) and intraperitoneal insulin tolerance test (IPITT) under normal chow (NC) and HFD conditions. Npgl overexpression promoted body mass gain and tended to increase food intake of NC-fed mice, whereas it had little effect on HFD-fed mice. The OGTT showed elevated blood glucose and insulin levels in Npgl-overexpressing NC-fed mice 15 min after glucose administration. Both the OGTT and IPITT demonstrated that Npgl overexpression decreased blood glucose levels in HFD-fed mice 60 min after glucose and insulin treatments. Notably, Npgl overexpression increased adipose tissue masses only in NC-fed mice, and it decreased blood glucose and insulin levels in HFD-fed mice at the experimental end point. It also increased the mRNA expression of galanin, one of the feeding and metabolic regulatory neuropeptides, in the hypothalamus of HFD-fed mice. Therefore, NPGL may alleviate HFD-induced hyperglycemia and insulin resistance in mice. View Full-Text
Keywords: neurosecretory protein GL; hypothalamus; neuropeptide; obesity; glucose homeostasis; insulin sensitivity neurosecretory protein GL; hypothalamus; neuropeptide; obesity; glucose homeostasis; insulin sensitivity
Show Figures

Figure 1

MDPI and ACS Style

Fukumura, K.; Narimatsu, Y.; Moriwaki, S.; Iwakoshi-Ukena, E.; Furumitsu, M.; Ukena, K. Effects of Overexpression of Neurosecretory Protein GL-Precursor Gene on Glucose Homeostasis and Insulin Sensitivity in Mice. Int. J. Mol. Sci. 2021, 22, 4681. https://doi.org/10.3390/ijms22094681

AMA Style

Fukumura K, Narimatsu Y, Moriwaki S, Iwakoshi-Ukena E, Furumitsu M, Ukena K. Effects of Overexpression of Neurosecretory Protein GL-Precursor Gene on Glucose Homeostasis and Insulin Sensitivity in Mice. International Journal of Molecular Sciences. 2021; 22(9):4681. https://doi.org/10.3390/ijms22094681

Chicago/Turabian Style

Fukumura, Keisuke, Yuki Narimatsu, Shogo Moriwaki, Eiko Iwakoshi-Ukena, Megumi Furumitsu, and Kazuyoshi Ukena. 2021. "Effects of Overexpression of Neurosecretory Protein GL-Precursor Gene on Glucose Homeostasis and Insulin Sensitivity in Mice" International Journal of Molecular Sciences 22, no. 9: 4681. https://doi.org/10.3390/ijms22094681

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop