Cellular Senescence and Inflammaging in the Skin Microenvironment
Abstract
:1. Introduction
2. Fibroblast Senescence
3. Keratinocyte Senescence
4. Aging-Associated Pigmentation and Melanocyte Senescence
5. Association between Skin Resident Immune Cells and Inflammaging
6. Concluding Remark
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
4EBP | 4E-binding protein 1 |
53BP1 | p53-binding protein 1 |
α-MSH | α-melanocyte stimulating hormone |
AhR | Aryl hydrocarbon receptor |
AP-1 | Activator protein 1 |
ATG | Autophagy related |
CCL2 | C-C motif chemokine ligand 2 |
CREB | Cyclic AMP-responsive element-binding protein |
CTGF | Connective tissue growth factor |
DC | Dendritic cell |
DNMT | DNA methyltransferase |
ECM | Extracellular matrix |
ERK | Extracellular signal-regulated kinase |
ET | Endothelin |
GF | Growth factor |
γH2AX | Gamma H2A histone family member X |
IGF | Insulin-like growth factor |
IL | Interleukin |
JNK | c-Jun N-terminal kinase |
LC3 | microtubule-associated protein 1A/1B-light chain 3 |
LCs | Langerhans cells |
MAPKAPK2 | MAP kinase Activated Protein Kinase 2 |
MAPKs | Mitogen-activated protein kinases |
MDC1 | Mediator of DNA checkpoint protein 1 |
MITF | Microphthalmia-associated transcription factor |
MMPs | Matrix metalloproteinases |
MNPs | Mononuclear phagocytes |
mTOR | Mammalian target of rapamycin |
NBS1 | Nijmegen breakage syndrome 1 protein |
NF-κB | Nuclear factor kappa-light-chain-enhancer of activated B cells |
ORM1 | Orosomucoid 1 protein |
PD-1 | Programmed cell death protein 1 |
PKA | Protein kinase A |
PM | Particulate matter |
POMC | Pro-opiomelanocortin |
ROS | Reactive oxygen species |
SA-β-gal | Senescence-associated β-galactosidase |
SASP | Senescence-associate secretory phenotype |
SCF | Stem cell factor |
SDF-1 | Stromal cell-derived factor-1 |
TAF | Telomere-associated DNA damage foci |
TGF | Tumor growth factor |
Th cell | T helper cell |
TNF-α | Tumor necrosis factor- α |
TRM | Tissue-resident memory T cell |
UVB | Ultraviolet B light |
UVR | UV radiation |
YBX-1 | Y-Box Binding Protein 1 |
ZO-1 | Zonula occludens-1 |
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Lee, Y.I.; Choi, S.; Roh, W.S.; Lee, J.H.; Kim, T.-G. Cellular Senescence and Inflammaging in the Skin Microenvironment. Int. J. Mol. Sci. 2021, 22, 3849. https://doi.org/10.3390/ijms22083849
Lee YI, Choi S, Roh WS, Lee JH, Kim T-G. Cellular Senescence and Inflammaging in the Skin Microenvironment. International Journal of Molecular Sciences. 2021; 22(8):3849. https://doi.org/10.3390/ijms22083849
Chicago/Turabian StyleLee, Young In, Sooyeon Choi, Won Seok Roh, Ju Hee Lee, and Tae-Gyun Kim. 2021. "Cellular Senescence and Inflammaging in the Skin Microenvironment" International Journal of Molecular Sciences 22, no. 8: 3849. https://doi.org/10.3390/ijms22083849