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Understanding the Future Prospects of Synergizing Minimally Invasive Transforaminal Lumbar Interbody Fusion Surgery with Ceramics and Regenerative Cellular Therapies

1
Department of Surgery, Division of Neurosurgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan
2
Department of Neurosurgery, Taipei Medical University Hospital, Taipei 11031, Taiwan
3
Taipei Neuroscience Institute, Taipei Medical University, Taipei 11031, Taiwan
4
Department of Medical Education and Research, Taipei Medical University Hospital, Taipei 11031, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editors: Inbo Han and Karin Wuertz-Kozak
Int. J. Mol. Sci. 2021, 22(7), 3638; https://doi.org/10.3390/ijms22073638
Received: 16 February 2021 / Revised: 22 March 2021 / Accepted: 26 March 2021 / Published: 31 March 2021
(This article belongs to the Special Issue Regeneration for Spinal Diseases)
Transforaminal lumber interbody fusion (TLIF) is the last resort to address the lumber degenerative disorders such as spondylolisthesis, causing lower back pain. The current surgical intervention for these abnormalities includes open TLIF. However, in recent years, minimally invasive TLIF (MIS-TLIF) has gained a high momentum, as it could minimize the risk of infection, blood loss, and post-operative complications pertaining to fusion surgery. Further advancement in visualizing and guiding techniques along with grafting cage and materials are continuously improving the safety and efficacy of MIS-TLIF. These assistive techniques are also playing a crucial role to increase and improve the learning curve of surgeons. However, achieving an appropriate output through TLIF still remains a challenge, which might be synergized through 3D-printing and tissue engineering-based regenerative therapy. Owing to their differentiation potential, biomaterials such as stem/progenitor cells may contribute to restructuring lost or damaged tissues during MIS-TLIF, and this therapeutic efficacy could be further supplemented by platelet-derived biomaterials, leading to improved clinical outcomes. Thus, based on the above-mentioned strategies, we have comprehensively summarized recent developments in MIS-TLIF and its possible combinatorial regenerative therapies for rapid and long-term relief. View Full-Text
Keywords: MIS-TLIF; bone graft; ceramics; stem cells; platelet-derived biomaterials MIS-TLIF; bone graft; ceramics; stem cells; platelet-derived biomaterials
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MDPI and ACS Style

Lo, W.-C.; Tsai, L.-W.; Yang, Y.-S.; Chan, R.W.Y. Understanding the Future Prospects of Synergizing Minimally Invasive Transforaminal Lumbar Interbody Fusion Surgery with Ceramics and Regenerative Cellular Therapies. Int. J. Mol. Sci. 2021, 22, 3638. https://doi.org/10.3390/ijms22073638

AMA Style

Lo W-C, Tsai L-W, Yang Y-S, Chan RWY. Understanding the Future Prospects of Synergizing Minimally Invasive Transforaminal Lumbar Interbody Fusion Surgery with Ceramics and Regenerative Cellular Therapies. International Journal of Molecular Sciences. 2021; 22(7):3638. https://doi.org/10.3390/ijms22073638

Chicago/Turabian Style

Lo, Wen-Cheng, Lung-Wen Tsai, Yi-Shan Yang, and Ryan W.Y. Chan. 2021. "Understanding the Future Prospects of Synergizing Minimally Invasive Transforaminal Lumbar Interbody Fusion Surgery with Ceramics and Regenerative Cellular Therapies" International Journal of Molecular Sciences 22, no. 7: 3638. https://doi.org/10.3390/ijms22073638

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