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Article

Tracing dsDNA Virus–Host Coevolution through Correlation of Their G-Quadruplex-Forming Sequences

1
Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 612 65 Brno, Czech Republic
2
Department of Experimental Biology, Faculty of Science, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic
3
Department of Biology and Ecology, Institute of Environmental Technologies, Faculty of Science, University of Ostrava, 710 00 Ostrava, Czech Republic
4
Faculty of Mechanical Engineering, Brno University of Technology, Technická 2896/2, 616 69 Brno, Czech Republic
5
Department of Informatics, Mendel University in Brno, Zemědělská 1, 613 00 Brno, Czech Republic
*
Author to whom correspondence should be addressed.
Academic Editor: James K. Bashkin
Int. J. Mol. Sci. 2021, 22(7), 3433; https://doi.org/10.3390/ijms22073433
Received: 2 March 2021 / Revised: 17 March 2021 / Accepted: 23 March 2021 / Published: 26 March 2021
(This article belongs to the Special Issue Impacts of Molecular Structure on Nucleic Acid-Protein Interactions)
The importance of gene expression regulation in viruses based upon G-quadruplex may point to its potential utilization in therapeutic targeting. Here, we present analyses as to the occurrence of putative G-quadruplex-forming sequences (PQS) in all reference viral dsDNA genomes and evaluate their dependence on PQS occurrence in host organisms using the G4Hunter tool. PQS frequencies differ across host taxa without regard to GC content. The overlay of PQS with annotated regions reveals the localization of PQS in specific regions. While abundance in some, such as repeat regions, is shared by all groups, others are unique. There is abundance within introns of Eukaryota-infecting viruses, but depletion of PQS in introns of bacteria-infecting viruses. We reveal a significant positive correlation between PQS frequencies in dsDNA viruses and corresponding hosts from archaea, bacteria, and eukaryotes. A strong relationship between PQS in a virus and its host indicates their close coevolution and evolutionarily reciprocal mimicking of genome organization. View Full-Text
Keywords: G-quadruplex; virus; bioinformatics; coevolution; host; dsDNA; G4Hunter G-quadruplex; virus; bioinformatics; coevolution; host; dsDNA; G4Hunter
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MDPI and ACS Style

Bohálová, N.; Cantara, A.; Bartas, M.; Kaura, P.; Šťastný, J.; Pečinka, P.; Fojta, M.; Brázda, V. Tracing dsDNA Virus–Host Coevolution through Correlation of Their G-Quadruplex-Forming Sequences. Int. J. Mol. Sci. 2021, 22, 3433. https://doi.org/10.3390/ijms22073433

AMA Style

Bohálová N, Cantara A, Bartas M, Kaura P, Šťastný J, Pečinka P, Fojta M, Brázda V. Tracing dsDNA Virus–Host Coevolution through Correlation of Their G-Quadruplex-Forming Sequences. International Journal of Molecular Sciences. 2021; 22(7):3433. https://doi.org/10.3390/ijms22073433

Chicago/Turabian Style

Bohálová, Natália, Alessio Cantara, Martin Bartas, Patrik Kaura, Jiří Šťastný, Petr Pečinka, Miroslav Fojta, and Václav Brázda. 2021. "Tracing dsDNA Virus–Host Coevolution through Correlation of Their G-Quadruplex-Forming Sequences" International Journal of Molecular Sciences 22, no. 7: 3433. https://doi.org/10.3390/ijms22073433

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