CircRNA—Protein Interactions in Muscle Development and Diseases
Abstract
:1. Introduction
2. Characterization of CircRNAs and RPBs
2.1. CircRNAs
2.1.1. Biogenesis of CircRNAs
2.1.2. Properties of CircRNAs
2.1.3. Regulating Mechanisms of CircRNAs
2.2. RBPs
2.2.1. Number and Properties of RBPs
2.2.2. RNA-Binding Domains of RBPs
3. RBPs Regulating CircRNA
3.1. RBPs Regulate the Synthesis and Degradation of CircRNA
3.2. RBPs Involved in the Modification and Editing of CircRNA
3.3. RBPs Participate in the Transportation of CircRNA
3.4. RBPs Control the Translation of CircRNA
4. CircRNAs Affecting RBPs
4.1. CircRNAs Can Serve as RBP Supermolecular Sponges
4.2. CircRNAs Participate in the Transportation of RBPs
4.3. CircRNAs Serve as Decoys for RBPs
4.4. CircRNAs Function as Scaffolds for RBPs
5. CircRNA–Protein Interactions Regulating Muscle Development and Diseases
5.1. Muscle Development
CircSamd4 and PURA/PURB
5.2. Muscle Related Diseases
5.2.1. CircAMOTL1 and ATK1/PDK1
5.2.2. CircFndc3b and FUS
5.2.3. CircNFIX and Ybx1/Nedd4-l
5.2.4. CircYAP and TMP4/ACTG
6. Strategies for Studying CircRNA–Protein Interactions
6.1. Bioinformatics Tools for CircRNA–Protein Interaction Prediction
6.2. Experimental Approaches for CircRNA–Protein Interactions Verification
6.2.1. CircRNA Pull-Down and RIP
6.2.2. RPA
6.2.3. FISH Co-Localization Assay
6.2.4. TRAP
7. Perspectives
8. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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CircRNA | RBP | Function | Cell | References |
---|---|---|---|---|
CircSamd4 | PURA/PURB | Myogenesis ↑ | C2C12 myoblasts | [20] |
CircAMOTL1 | ATK1/PDK1 | Cell proliferation and survival ↑ | YPEN and MCF-7 | [87] |
CircFndc3b | FUS | Angiogenesis ↑ Cardiomyocyte apoptosis ↓ | MCECs | [89] |
CircNFIX | Ybx1/Nedd4-1 | Cardiomyocyte proliferation ↓ | Cardiomyocytes | [90] |
CircYAP | TMP4/ACTG | Cardiac fibrosis ↓ | MCFs and HL-1 | [91] |
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Zheng, S.; Zhang, X.; Odame, E.; Xu, X.; Chen, Y.; Ye, J.; Zhou, H.; Dai, D.; Kyei, B.; Zhan, S.; et al. CircRNA—Protein Interactions in Muscle Development and Diseases. Int. J. Mol. Sci. 2021, 22, 3262. https://doi.org/10.3390/ijms22063262
Zheng S, Zhang X, Odame E, Xu X, Chen Y, Ye J, Zhou H, Dai D, Kyei B, Zhan S, et al. CircRNA—Protein Interactions in Muscle Development and Diseases. International Journal of Molecular Sciences. 2021; 22(6):3262. https://doi.org/10.3390/ijms22063262
Chicago/Turabian StyleZheng, Shuailong, Xujia Zhang, Emmanuel Odame, Xiaoli Xu, Yuan Chen, Jiangfeng Ye, Helin Zhou, Dinghui Dai, Bismark Kyei, Siyuan Zhan, and et al. 2021. "CircRNA—Protein Interactions in Muscle Development and Diseases" International Journal of Molecular Sciences 22, no. 6: 3262. https://doi.org/10.3390/ijms22063262