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Open AccessReview

CircRNA—Protein Interactions in Muscle Development and Diseases

Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China
Authors to whom correspondence should be addressed.
Academic Editor: Yuri Lyubchenko
Int. J. Mol. Sci. 2021, 22(6), 3262;
Received: 23 February 2021 / Revised: 17 March 2021 / Accepted: 19 March 2021 / Published: 23 March 2021
(This article belongs to the Section Molecular Biophysics)
Circular RNA (circRNA) is a kind of novel endogenous noncoding RNA formed through back-splicing of mRNA precursor. The biogenesis, degradation, nucleus–cytoplasm transport, location, and even translation of circRNA are controlled by RNA-binding proteins (RBPs). Therefore, circRNAs and the chaperoned RBPs play critical roles in biological functions that significantly contribute to normal animal development and disease. In this review, we systematically characterize the possible molecular mechanism of circRNA–protein interactions, summarize the latest research on circRNA–protein interactions in muscle development and myocardial disease, and discuss the future application of circRNA in treating muscle diseases. Finally, we provide several valid prediction methods and experimental verification approaches. Our review reveals the significance of circRNAs and their protein chaperones and provides a reference for further study in this field. View Full-Text
Keywords: muscle; circRNA; RNA-binding protein; molecular interactions; function muscle; circRNA; RNA-binding protein; molecular interactions; function
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MDPI and ACS Style

Zheng, S.; Zhang, X.; Odame, E.; Xu, X.; Chen, Y.; Ye, J.; Zhou, H.; Dai, D.; Kyei, B.; Zhan, S.; Cao, J.; Guo, J.; Zhong, T.; Wang, L.; Li, L.; Zhang, H. CircRNA—Protein Interactions in Muscle Development and Diseases. Int. J. Mol. Sci. 2021, 22, 3262.

AMA Style

Zheng S, Zhang X, Odame E, Xu X, Chen Y, Ye J, Zhou H, Dai D, Kyei B, Zhan S, Cao J, Guo J, Zhong T, Wang L, Li L, Zhang H. CircRNA—Protein Interactions in Muscle Development and Diseases. International Journal of Molecular Sciences. 2021; 22(6):3262.

Chicago/Turabian Style

Zheng, Shuailong; Zhang, Xujia; Odame, Emmanuel; Xu, Xiaoli; Chen, Yuan; Ye, Jiangfeng; Zhou, Helin; Dai, Dinghui; Kyei, Bismark; Zhan, Siyuan; Cao, Jiaxue; Guo, Jiazhong; Zhong, Tao; Wang, Linjie; Li, Li; Zhang, Hongping. 2021. "CircRNA—Protein Interactions in Muscle Development and Diseases" Int. J. Mol. Sci. 22, no. 6: 3262.

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