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A Mitocentric View of the Main Bacterial and Parasitic Infectious Diseases in the Pediatric Population

1
Faculty of Medicine, Pompeu Fabra University and Universitat Autònoma de Barcelona, 08002 Barcelona, Spain
2
School of Biological and Environmental Sciences, Liverpool John Moores University, Liverpool L2 2QP, UK
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Malalties Infeccioses i Resposta Inflamatòria Sistèmica en Pediatria, Unitat d’Infeccions, Servei de Pediatria, Institut de Recerca Pediàtrica Hospital Sant Joan de Déu, 08950 Barcelona, Spain
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Faculty of Medicine and Health Sciences, University of Barcelona, 08036 Barcelona, Spain
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Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain
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Red de Investigación Translacional en Infectología Pediátrica (RITIP), 28029 Madrid, Spain
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Muscle Research and Mitochondrial Function Laboratory, Cellex-IDIBAPS, Faculty of Medicine and Health Sciences, University of Barcelona, 08036 Barcelona, Spain
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Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) (ISCIII), 28029 Madrid, Spain
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Internal Medicine Department-Hospital Clínic of Barcelona (HCB), 08036 Barcelona, Spain
*
Authors to whom correspondence should be addressed.
Academic Editor: Pablo M. García-Rovés
Int. J. Mol. Sci. 2021, 22(6), 3272; https://doi.org/10.3390/ijms22063272
Received: 10 February 2021 / Revised: 13 March 2021 / Accepted: 16 March 2021 / Published: 23 March 2021
(This article belongs to the Special Issue Mitochondrial Function and Communication)
Infectious diseases occur worldwide with great frequency in both adults and children. Both infections and their treatments trigger mitochondrial interactions at multiple levels: (i) incorporation of damaged or mutated proteins to the complexes of the electron transport chain, (ii) mitochondrial genome (depletion, deletions, and point mutations) and mitochondrial dynamics (fusion and fission), (iii) membrane potential, (iv) apoptotic regulation, (v) generation of reactive oxygen species, among others. Such alterations may result in serious adverse clinical events with great impact on children’s quality of life, even resulting in death. As such, bacterial agents are frequently associated with loss of mitochondrial membrane potential and cytochrome c release, ultimately leading to mitochondrial apoptosis by activation of caspases-3 and -9. Using Rayyan QCRI software for systematic reviews, we explore the association between mitochondrial alterations and pediatric infections including (i) bacterial: M. tuberculosis, E. cloacae, P. mirabilis, E. coli, S. enterica, S. aureus, S. pneumoniae, N. meningitidis and (ii) parasitic: P. falciparum. We analyze how these pediatric infections and their treatments may lead to mitochondrial deterioration in this especially vulnerable population, with the intention of improving both the understanding of these diseases and their management in clinical practice. View Full-Text
Keywords: antibiotics; infections; mitochondria; pediatrics antibiotics; infections; mitochondria; pediatrics
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MDPI and ACS Style

Romero-Cordero, S.; Kirwan, R.; Noguera-Julian, A.; Cardellach, F.; Fortuny, C.; Morén, C. A Mitocentric View of the Main Bacterial and Parasitic Infectious Diseases in the Pediatric Population. Int. J. Mol. Sci. 2021, 22, 3272. https://doi.org/10.3390/ijms22063272

AMA Style

Romero-Cordero S, Kirwan R, Noguera-Julian A, Cardellach F, Fortuny C, Morén C. A Mitocentric View of the Main Bacterial and Parasitic Infectious Diseases in the Pediatric Population. International Journal of Molecular Sciences. 2021; 22(6):3272. https://doi.org/10.3390/ijms22063272

Chicago/Turabian Style

Romero-Cordero, Sonia, Richard Kirwan, Antoni Noguera-Julian, Francesc Cardellach, Clàudia Fortuny, and Constanza Morén. 2021. "A Mitocentric View of the Main Bacterial and Parasitic Infectious Diseases in the Pediatric Population" International Journal of Molecular Sciences 22, no. 6: 3272. https://doi.org/10.3390/ijms22063272

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