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Chemical Constituents of the Bulbs of Scilla peruviana and Their Pancreatic Lipase Inhibitory Activity

School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1, Horinouchi, Hachioji, Tokyo 192-0392, Japan
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Academic Editor: Charles Brennan
Int. J. Mol. Sci. 2021, 22(3), 1262; https://doi.org/10.3390/ijms22031262
Received: 13 January 2021 / Accepted: 26 January 2021 / Published: 27 January 2021
(This article belongs to the Section Bioactives and Nutraceuticals)
Scilla species are used as medicinal plants and contain lanosterol-type triterpene glycosides. The phytochemical investigation of the bulbs of Scilla peruviana led to the isolation of 17 compounds, including three new rearranged pentacyclic-lanosterol glycosides (13) and two new homoisoflavanone glycosides (12 and 13). The structures of the undescribed compounds were determined by extensive spectroscopic analyses, including two-dimensional (2D) NMR. Among the triterpene glycosides, 2, 3, and 6 showed significant pancreatic lipase inhibitory activity in a concentration-dependent manner in vitro. The oral administration of scillascilloside D-2 (6) reduced serum triglyceride levels in a dose-dependent manner in soybean oil-loaded mice. View Full-Text
Keywords: Scilla peruviana; Asparagaceae; triterpene; lanosterol glycoside; homoisoflavanone; pancreatic lipase Scilla peruviana; Asparagaceae; triterpene; lanosterol glycoside; homoisoflavanone; pancreatic lipase
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MDPI and ACS Style

Matsuo, Y.; Yamashiro, A.; Ootomo, K.; Nakagawa, M.; Tsuchihashi, H.; Inaba, N.; Mimaki, Y. Chemical Constituents of the Bulbs of Scilla peruviana and Their Pancreatic Lipase Inhibitory Activity. Int. J. Mol. Sci. 2021, 22, 1262. https://doi.org/10.3390/ijms22031262

AMA Style

Matsuo Y, Yamashiro A, Ootomo K, Nakagawa M, Tsuchihashi H, Inaba N, Mimaki Y. Chemical Constituents of the Bulbs of Scilla peruviana and Their Pancreatic Lipase Inhibitory Activity. International Journal of Molecular Sciences. 2021; 22(3):1262. https://doi.org/10.3390/ijms22031262

Chicago/Turabian Style

Matsuo, Yukiko, Asuka Yamashiro, Kanae Ootomo, Mika Nakagawa, Hiroko Tsuchihashi, Niro Inaba, and Yoshihiro Mimaki. 2021. "Chemical Constituents of the Bulbs of Scilla peruviana and Their Pancreatic Lipase Inhibitory Activity" International Journal of Molecular Sciences 22, no. 3: 1262. https://doi.org/10.3390/ijms22031262

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