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Article

Comparison of Bone Regeneration in Different Forms of Bovine Bone Scaffolds with Recombinant Human Bone Morphogenetic Protein-2

1
Department of Oral and Maxillofacial Surgery, School of Dentistry, Jeonbuk National University, Jeonju 54896, Korea
2
Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju 54896, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Francesca Paino
Int. J. Mol. Sci. 2021, 22(20), 11121; https://doi.org/10.3390/ijms222011121
Received: 15 September 2021 / Revised: 12 October 2021 / Accepted: 13 October 2021 / Published: 15 October 2021
The aim of this study was to compare the bone regeneration ability of particle and block bones, acting as bone scaffolds, with recombinant human bone morphogenetic protein (rhBMP)-2 and evaluate them as rhBMP-2 carriers. Demineralized bovine bone particles, blocks, and rhBMP-2 were grafted into the subperiosteal space of a rat calvarial bone, and the rats were randomly divided into four groups: particle, block, P (particle)+BMP, and B (block)+BMP groups. The bone volume of the B+BMP group was significantly higher than that of the other groups (p < 0.00), with no significant difference in bone mineral density. The average adipose tissue volume of the B+BMP group was higher than that of the P+BMP group, although the difference was not significant. Adipose tissue formation was observed in the rhBMP-2 application group. Histologically, the particle and B+BMP groups showed higher formation of a new bone. However, adipose tissue and void spaces were also formed, especially in the B+BMP group. Hence, despite the formation of a large central void space, rhBMP-2 could be effectively used with block bone scaffolds and showed excellent new bone formation. Further studies are required to evaluate the changes in adipose tissue. View Full-Text
Keywords: bone morphogenetic protein; bovine bone; bone regeneration; adipose tissue bone morphogenetic protein; bovine bone; bone regeneration; adipose tissue
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MDPI and ACS Style

Seok, H.; Kim, H.-Y.; Kang, D.-C.; Park, J.-H.; Park, J.H. Comparison of Bone Regeneration in Different Forms of Bovine Bone Scaffolds with Recombinant Human Bone Morphogenetic Protein-2. Int. J. Mol. Sci. 2021, 22, 11121. https://doi.org/10.3390/ijms222011121

AMA Style

Seok H, Kim H-Y, Kang D-C, Park J-H, Park JH. Comparison of Bone Regeneration in Different Forms of Bovine Bone Scaffolds with Recombinant Human Bone Morphogenetic Protein-2. International Journal of Molecular Sciences. 2021; 22(20):11121. https://doi.org/10.3390/ijms222011121

Chicago/Turabian Style

Seok, Hyun, Hee-Youl Kim, Dong-Cheol Kang, Jung-Ho Park, and Jong H. Park. 2021. "Comparison of Bone Regeneration in Different Forms of Bovine Bone Scaffolds with Recombinant Human Bone Morphogenetic Protein-2" International Journal of Molecular Sciences 22, no. 20: 11121. https://doi.org/10.3390/ijms222011121

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