Next Article in Journal
Possible Roles of Interleukin-4 and -13 and Their Receptors in Gastric and Colon Cancer
Next Article in Special Issue
Genetic and Environmental Factors Influence the Pleomorphy of LRRK2 Parkinsonism
Previous Article in Journal
The Role of Endogenous Antimicrobial Peptides in Modulating Innate Immunity of the Ocular Surface in Dry Eye Diseases
Previous Article in Special Issue
The Role of Alpha-Synuclein and Other Parkinson’s Genes in Neurodevelopmental and Neurodegenerative Disorders
 
 
Article

Expression Levels of an Alpha-Synuclein Transcript in Blood May Distinguish between Early Dementia with Lewy Bodies and Parkinson’s Disease

1
Department of Pathology, Germans Trias i Pujol Research Institute (IGTP), Universitat Autònoma de Barcelona (UAB), 08193 Barcelona, Spain
2
Servei de Neurologia, Hospital Universitari Bellvitge, 08907 L’Hospitalet de Llobregat, Spain
3
Servei de Neurologia, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Spain
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(2), 725; https://doi.org/10.3390/ijms22020725
Received: 30 November 2020 / Revised: 9 January 2021 / Accepted: 11 January 2021 / Published: 13 January 2021
Lewy body diseases (LBD) including dementia with Lewy bodies (DLB) and Parkinson disease (PD) are characterized by alpha-synuclein pathology. DLB is difficult to diagnose and peripheral biomarkers are urgently needed. Therefore, we analyzed the expression of five alpha-synuclein gene (SNCA) transcripts, SNCAtv1, SNCAtv2, SNCAtv3, SNCA126, and SNCA112, in 45 LBD and control temporal cortex samples and in the blood of 72 DLB, 59 PD, and 54 control subjects. The results revealed overexpression of SNCAtv1 and SNCA112 in DLB, and SNCAtv2 in PD temporal cortices. In DLB blood, diminution of all SNCA transcripts was observed. SNCAtv1 and SNCAtv2 were diminished in PD with disease onset before 70 years. SNCAtv3, driven by its own promoter, showed opposite expression in early DLB and PD, suggesting that its amount may be an early, DLB specific biomarker. Correlation between blood transcript levels and disease duration was positive in DLB and negative in PD, possibly reflecting differences in brain alpha-synuclein aggregation rates associated with differences in disease courses. In conclusion, SNCA transcripts showed a disease-specific increase in the brain and were diminished in blood of LBD patients. SNCAtv3 expression was decreased in early DLB and increased in early PD and could be a biomarker for early DLB diagnosis. View Full-Text
Keywords: alpha-synuclein; SNCA transcript variants; dementia with Lewy bodies; Parkinson’s disease; differential mRNA transcript expression; peripheral biomarker; disease progression alpha-synuclein; SNCA transcript variants; dementia with Lewy bodies; Parkinson’s disease; differential mRNA transcript expression; peripheral biomarker; disease progression
Show Figures

Figure 1

MDPI and ACS Style

Marsal-García, L.; Urbizu, A.; Arnaldo, L.; Campdelacreu, J.; Vilas, D.; Ispierto, L.; Gascón-Bayarri, J.; Reñé, R.; Álvarez, R.; Beyer, K. Expression Levels of an Alpha-Synuclein Transcript in Blood May Distinguish between Early Dementia with Lewy Bodies and Parkinson’s Disease. Int. J. Mol. Sci. 2021, 22, 725. https://doi.org/10.3390/ijms22020725

AMA Style

Marsal-García L, Urbizu A, Arnaldo L, Campdelacreu J, Vilas D, Ispierto L, Gascón-Bayarri J, Reñé R, Álvarez R, Beyer K. Expression Levels of an Alpha-Synuclein Transcript in Blood May Distinguish between Early Dementia with Lewy Bodies and Parkinson’s Disease. International Journal of Molecular Sciences. 2021; 22(2):725. https://doi.org/10.3390/ijms22020725

Chicago/Turabian Style

Marsal-García, Laura, Aintzane Urbizu, Laura Arnaldo, Jaume Campdelacreu, Dolores Vilas, Lourdes Ispierto, Jordi Gascón-Bayarri, Ramón Reñé, Ramiro Álvarez, and Katrin Beyer. 2021. "Expression Levels of an Alpha-Synuclein Transcript in Blood May Distinguish between Early Dementia with Lewy Bodies and Parkinson’s Disease" International Journal of Molecular Sciences 22, no. 2: 725. https://doi.org/10.3390/ijms22020725

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop