Phospho-Tau and Chromatin Landscapes in Early and Late Alzheimer’s Disease
Abstract
:1. Introduction
2. Nucleosomes, Chromatin Types, and Nuclear Architecture
3. Nuclear Tau Modifies the Chromatin Landscape
4. Epigenetic Histone Code, Nuclear Tau, and Chromatin Aging
5. Different Chromatin Landscapes Associated to Early and Late Ad Stages
6. Conclusions and Future Directions
Author Contributions
Funding
Conflicts of Interest
References
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Epigenetic Stages in Neurons |
---|
Aging: condensed global chromatin and nuclear tau |
ON transcriptionally repressive marks (heterochromatin): H3K9me3 |
OFF transcriptionally active marks (euchromatin): H4K16ac |
Dysregulated: H4K12ac |
Nuclear tau: AT100 increase and expression of AT8 |
Early Alzheimer’s Diease: Condensed heterochromatin (LADs, NADs) and Lamin A |
ON transcriptionally repressive marks (constitutive heterochromatin): H3K9me3, H4K20me3 |
ON hippocampal HDAC2 expression |
OFF transcriptionally active marks (euchromatin): H4K16ac |
Ectopic cytoplasmic localization: H3K4me3, DNA methyltransferase 1, RNA Pol II |
Nuclear tau: fading |
Late Alzheimer’s Diease: Decondensed global chromatin and cytoplasmic tau |
ON global acetylation |
OFF methylation (heterochromatin): H3K9me2, H4K20me3 |
ON H3K9ac (euchromatin and heterochromatin) |
Cytosolic tau: Tangles |
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Gil, L.; Niño, S.A.; Guerrero, C.; Jiménez-Capdeville, M.E. Phospho-Tau and Chromatin Landscapes in Early and Late Alzheimer’s Disease. Int. J. Mol. Sci. 2021, 22, 10283. https://doi.org/10.3390/ijms221910283
Gil L, Niño SA, Guerrero C, Jiménez-Capdeville ME. Phospho-Tau and Chromatin Landscapes in Early and Late Alzheimer’s Disease. International Journal of Molecular Sciences. 2021; 22(19):10283. https://doi.org/10.3390/ijms221910283
Chicago/Turabian StyleGil, Laura, Sandra A. Niño, Carmen Guerrero, and María E. Jiménez-Capdeville. 2021. "Phospho-Tau and Chromatin Landscapes in Early and Late Alzheimer’s Disease" International Journal of Molecular Sciences 22, no. 19: 10283. https://doi.org/10.3390/ijms221910283