Evaluation of Wound Healing Activity of Salvianolic Acid B on In Vitro Experimental Model
1
Department of Molecular and Cellular Biology, Wroclaw Medical University, 50-556 Wroclaw, Poland
2
Department of Animal Developmental Biology, Institute of Experimental Biology, University of Wroclaw, 50-328 Wroclaw, Poland
3
Department of Pharmaceutical Biochemistry, Wroclaw Medical University, ul. Borowska 211A, 50-556 Wroclaw, Poland
*
Authors to whom correspondence should be addressed.
Academic Editor: Henrik Franzyk
Int. J. Mol. Sci. 2021, 22(14), 7728; https://doi.org/10.3390/ijms22147728
Received: 1 July 2021
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Revised: 9 July 2021
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Accepted: 15 July 2021
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Published: 20 July 2021
(This article belongs to the Special Issue Natural Product Pharmacology)
Despite a wide range of bactericides and antiseptics, the treatment of chronic or complicated wounds is still a major challenge for modern medicine. Topical medications are the most sought-after new agents for use as treatment. The therapeutic concentration of their active substances is easy to achieve with the lowest possible burden on the patient’s body. This study assesses the effect of salvianolic acid B (Sal B) on the proliferation, migration, and production of collagen type III by fibroblasts, which are the most important processes in wound healing. The study was conducted on human gingival fibroblasts obtained from primary cell culture. The results showed that Sal B at a dose of 75 µg/mL increases the cell viability with significant stimulation of the cell migration as demonstrated in the wound healing assay, as well as an increase in the expression of collagen type III, which has great importance in the initial stages of wound scarring. The results obtained in the conducted studies and previous scientific reports on the antibacterial properties and low toxicity of Sal B indicate its high potential in wound healing.
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Keywords:
wound healing; salvianolic acid B; cell migration; collagen; Danshen
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MDPI and ACS Style
Szwedowicz, U.; Szewczyk, A.; Gołąb, K.; Choromańska, A. Evaluation of Wound Healing Activity of Salvianolic Acid B on In Vitro Experimental Model. Int. J. Mol. Sci. 2021, 22, 7728. https://doi.org/10.3390/ijms22147728
AMA Style
Szwedowicz U, Szewczyk A, Gołąb K, Choromańska A. Evaluation of Wound Healing Activity of Salvianolic Acid B on In Vitro Experimental Model. International Journal of Molecular Sciences. 2021; 22(14):7728. https://doi.org/10.3390/ijms22147728
Chicago/Turabian StyleSzwedowicz, Urszula, Anna Szewczyk, Krzysztof Gołąb, and Anna Choromańska. 2021. "Evaluation of Wound Healing Activity of Salvianolic Acid B on In Vitro Experimental Model" International Journal of Molecular Sciences 22, no. 14: 7728. https://doi.org/10.3390/ijms22147728
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