Next Article in Journal
Immune Aging and Immunotherapy in Cancer
Next Article in Special Issue
FTY720 Inhibits Expansion of Breast Cancer Stem Cells via PP2A Activation
Previous Article in Journal
Bifunctional Role of CrkL during Bone Remodeling
Previous Article in Special Issue
Plumbagin, a Natural Product with Potent Anticancer Activities, Binds to and Inhibits Dihydroorotase, a Key Enzyme in Pyrimidine Biosynthesis
 
 
Article

Dextran-Curcumin Nanosystems Inhibit Cell Growth and Migration Regulating the Epithelial to Mesenchymal Transition in Prostate Cancer Cells

1
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy
2
Lowy Cancer Research Centre, Children’s Cancer Institute, University of New South Wales, High Street, Randwick, NSW 2052, Australia
3
School of Women’s and Children’s Health, University of New South Wales, Kensington, NSW 2052, Australia
4
ARC Centre of Excellence for Convergent BioNano Science and Technology, Australian Centre for NanoMedicine, University of New South Wales, Kensington, NSW 2052, Australia
*
Author to whom correspondence should be addressed.
Academic Editor: Silvie Rimpelova
Int. J. Mol. Sci. 2021, 22(13), 7013; https://doi.org/10.3390/ijms22137013
Received: 20 May 2021 / Revised: 21 June 2021 / Accepted: 25 June 2021 / Published: 29 June 2021
(This article belongs to the Special Issue Quo Vadis Cancer Research? On Molecular Mechanisms and Drug Discovery)
Functional nanocarriers which are able to simultaneously vectorize drugs to the site of interest and exert their own cytotoxic activity represent a significant breakthrough in the search for effective anticancer strategies with fewer side effects than conventional chemotherapeutics. Here, we propose previously developed, self-assembling dextran-curcumin nanoparticles for the treatment of prostate cancer in combination therapy with Doxorubicin (DOXO). Biological effectiveness was investigated by evaluating the cell viability in either cancer and normal cells, reactive oxygen species (ROS) production, apoptotic effect, interference with the cell cycle, and the ability to inhibit cell migration and reverse the epithelial to mesenchymal transition (EMT). The results proved a significant enhancement of curcumin efficiency upon immobilization in nanoparticles: IC50 reduced by a half, induction of apoptotic effect, and improved ROS production (from 67 to 134%) at low concentrations. Nanoparticles guaranteed a pH-dependent DOXO release, with a more efficient release in acidic environments. Finally, a synergistic effect between nanoparticles and Doxorubicin was demonstrated, with the free curcumin showing additive activity. Although in vivo studies are required to support the findings of this study, these preliminary in vitro data can be considered a proof of principle for the design of an effective therapy for prostate cancer treatment. View Full-Text
Keywords: prostate cancer; self-assembling nanoparticles; combination therapy; curcumin; epithelial to mesenchymal transition prostate cancer; self-assembling nanoparticles; combination therapy; curcumin; epithelial to mesenchymal transition
Show Figures

Figure 1

MDPI and ACS Style

Bevacqua, E.; Curcio, M.; Saletta, F.; Vittorio, O.; Cirillo, G.; Tucci, P. Dextran-Curcumin Nanosystems Inhibit Cell Growth and Migration Regulating the Epithelial to Mesenchymal Transition in Prostate Cancer Cells. Int. J. Mol. Sci. 2021, 22, 7013. https://doi.org/10.3390/ijms22137013

AMA Style

Bevacqua E, Curcio M, Saletta F, Vittorio O, Cirillo G, Tucci P. Dextran-Curcumin Nanosystems Inhibit Cell Growth and Migration Regulating the Epithelial to Mesenchymal Transition in Prostate Cancer Cells. International Journal of Molecular Sciences. 2021; 22(13):7013. https://doi.org/10.3390/ijms22137013

Chicago/Turabian Style

Bevacqua, Emilia, Manuela Curcio, Federica Saletta, Orazio Vittorio, Giuseppe Cirillo, and Paola Tucci. 2021. "Dextran-Curcumin Nanosystems Inhibit Cell Growth and Migration Regulating the Epithelial to Mesenchymal Transition in Prostate Cancer Cells" International Journal of Molecular Sciences 22, no. 13: 7013. https://doi.org/10.3390/ijms22137013

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop