Next Article in Journal
Interaction between Metformin, Folate and Vitamin B12 and the Potential Impact on Fetal Growth and Long-Term Metabolic Health in Diabetic Pregnancies
Next Article in Special Issue
Molecular Alterations in Gastric Preneoplastic Lesions and Early Gastric Cancer
Previous Article in Journal
Investigating the Antifungal Mechanism of Action of Polygodial by Phenotypic Screening in Saccharomyces cerevisiae
Previous Article in Special Issue
Small Bowel Epithelial Precursor Lesions: A Focus on Molecular Alterations
Review

Molecular Alterations in Gastric Intestinal Metaplasia

Department of Gastroenterology, Lithuanian University of Health Sciences, 50161 Kaunas, Lithuania
*
Author to whom correspondence should be addressed.
Academic Editor: Luca Saragoni
Int. J. Mol. Sci. 2021, 22(11), 5758; https://doi.org/10.3390/ijms22115758
Received: 30 April 2021 / Revised: 24 May 2021 / Accepted: 26 May 2021 / Published: 28 May 2021
(This article belongs to the Special Issue Molecular Alterations in GastroIntestinal Pre-invasive Lesions)
Gastric cancer (GC) remains one of the most common causes of mortality worldwide. Intestinal metaplasia (IM) is one of the preneoplastic gastric lesions and is considered an essential predisposing factor in GC development. Here we present a review of recent most relevant papers to summarize major findings on the molecular alterations in gastric IM. The latest progress in novel diagnostic methods allows scientists to identify various types of molecular alterations in IM, such as polymorphisms in various genes, changes in the expression of micro-RNAs and long noncoding RNAs, and altered microbiome profiles. The results have shown that some of these alterations have strong associations with IM and a potential to be used for screening, treatment, and prognostic purposes; however, one of the most important limiting factors is the inhomogeneity of the studies. Therefore, further large-scale studies and clinical trials with standardized methods designed by multicenter consortiums are needed. As of today, various molecular alterations in IM could become a part of personalized medicine in the near future, which would help us deliver a personalized approach for each patient and identify those at risk of progression to GC. View Full-Text
Keywords: intestinal metaplasia; molecular alterations; genetic variations; micro-RNAs; microbiome; gastric cancer intestinal metaplasia; molecular alterations; genetic variations; micro-RNAs; microbiome; gastric cancer
Show Figures

Figure 1

MDPI and ACS Style

Jonaitis, P.; Kupcinskas, L.; Kupcinskas, J. Molecular Alterations in Gastric Intestinal Metaplasia. Int. J. Mol. Sci. 2021, 22, 5758. https://doi.org/10.3390/ijms22115758

AMA Style

Jonaitis P, Kupcinskas L, Kupcinskas J. Molecular Alterations in Gastric Intestinal Metaplasia. International Journal of Molecular Sciences. 2021; 22(11):5758. https://doi.org/10.3390/ijms22115758

Chicago/Turabian Style

Jonaitis, Paulius, Limas Kupcinskas, and Juozas Kupcinskas. 2021. "Molecular Alterations in Gastric Intestinal Metaplasia" International Journal of Molecular Sciences 22, no. 11: 5758. https://doi.org/10.3390/ijms22115758

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop