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Review

Angiogenic Properties of Placenta-Derived Extracellular Vesicles in Normal Pregnancy and in Preeclampsia

1
Department of Molecular Biotechnology and Health Sciences, University of Torino, 10124 Torino, Italy
2
Aston Medical Research Institute, Aston Medical School, Aston University, Birmingham B4 7ET, UK
*
Author to whom correspondence should be addressed.
Academic Editors: Heriberto Rodriguez-Martinez, Jordi Roca and Emilio A. Martinez
Int. J. Mol. Sci. 2021, 22(10), 5402; https://doi.org/10.3390/ijms22105402
Received: 13 April 2021 / Revised: 14 May 2021 / Accepted: 17 May 2021 / Published: 20 May 2021
(This article belongs to the Special Issue Extracellular Vesicles in Reproduction 2.0)
Angiogenesis is one of the main processes that coordinate the biological events leading to a successful pregnancy, and its imbalance characterizes several pregnancy-related diseases, including preeclampsia. Intracellular interactions via extracellular vesicles (EVs) contribute to pregnancy’s physiology and pathophysiology, and to the fetal–maternal interaction. The present review outlines the implications of EV-mediated crosstalk in the angiogenic process in healthy pregnancy and its dysregulation in preeclampsia. In particular, the effect of EVs derived from gestational tissues in pro and anti-angiogenic processes in the physiological and pathological setting is described. Moreover, the application of EVs from placental stem cells in the clinical setting is reported. View Full-Text
Keywords: extracellular vesicles; preeclampsia; angiogenesis extracellular vesicles; preeclampsia; angiogenesis
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MDPI and ACS Style

Gebara, N.; Correia, Y.; Wang, K.; Bussolati, B. Angiogenic Properties of Placenta-Derived Extracellular Vesicles in Normal Pregnancy and in Preeclampsia. Int. J. Mol. Sci. 2021, 22, 5402. https://doi.org/10.3390/ijms22105402

AMA Style

Gebara N, Correia Y, Wang K, Bussolati B. Angiogenic Properties of Placenta-Derived Extracellular Vesicles in Normal Pregnancy and in Preeclampsia. International Journal of Molecular Sciences. 2021; 22(10):5402. https://doi.org/10.3390/ijms22105402

Chicago/Turabian Style

Gebara, Natalia, Yolanda Correia, Keqing Wang, and Benedetta Bussolati. 2021. "Angiogenic Properties of Placenta-Derived Extracellular Vesicles in Normal Pregnancy and in Preeclampsia" International Journal of Molecular Sciences 22, no. 10: 5402. https://doi.org/10.3390/ijms22105402

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