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New Perspectives in Food Allergy
Open AccessReview

Overcoming Shellfish Allergy: How Far Have We Come?

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Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
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Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Shatin, Hong Kong
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School of Life Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong
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Division of Rheumatology/Allergy, School of Medicine, University of California, Davis, CA 95616, USA
*
Author to whom correspondence should be addressed.
Short title: Management of shellfish allergy.
Int. J. Mol. Sci. 2020, 21(6), 2234; https://doi.org/10.3390/ijms21062234
Received: 30 January 2020 / Revised: 3 March 2020 / Accepted: 19 March 2020 / Published: 23 March 2020
(This article belongs to the Special Issue Molecular and Cellular Basis of Food Allergies)
Shellfish allergy caused by undesirable immunological responses upon ingestion of crustaceans and mollusks is a common cause of food allergy, especially in the Asia-Pacific region. While the prevalence of shellfish allergy is increasing, the mainstay of clinical diagnosis for these patients includes extract-based skin prick test and specific IgE measurement while clinical management consists of food avoidance and as-needed use of adrenaline autoinjector should they develop severe allergic reactions. Such a standard of care is unsatisfactory to both patients and healthcare practitioners. There is a pressing need to introduce more specific diagnostic methods, as well as effective and safe therapies for patients with shellfish allergy. Knowledge gained on the identifications and defining the immuno-molecular features of different shellfish allergens over the past two decades have gradually translated into the design of new diagnostic and treatment options for shellfish allergy. In this review, we will discuss the epidemiology, the molecular identification of shellfish allergens, recent progress in various diagnostic methods, as well as current development in immunotherapeutic approaches including the use of unmodified allergens, hypoallergens, immunoregulatory peptides and DNA vaccines for the prevention and treatment of shellfish allergy. The prospect of a “cure “for shellfish allergy is within reach. View Full-Text
Keywords: allergen-specific immunotherapy; component-resolved diagnosis; diagnosis; DNA vaccine; tropomyosin allergen-specific immunotherapy; component-resolved diagnosis; diagnosis; DNA vaccine; tropomyosin
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Wai, C.Y.; Leung, N.Y.; Chu, K.H.; Leung, P.S.; Leung, A.S.; Wong, G.W.; Leung, T.F. Overcoming Shellfish Allergy: How Far Have We Come? Int. J. Mol. Sci. 2020, 21, 2234.

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