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Sirtuin-1 and Its Relevance in Vascular Calcification

Research Models for Studying Vascular Calcification

Campus Benjamin Franklin, Department of Nephrology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universtität zu Berlin, and Berlin Institute of Health, Hindenburgdamm 30, 12203 Berlin, Germany
Department of Chemistry, Biochemistry and Pharmacy, Freie Universität Berlin, Königin-Luise-Straβe 2+4, 14195 Berlin, Germany
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(6), 2204;
Received: 2 March 2020 / Revised: 17 March 2020 / Accepted: 18 March 2020 / Published: 23 March 2020
(This article belongs to the Special Issue Mechanisms of Vascular Calcification)
Calcification of the vessel wall contributes to high cardiovascular morbidity and mortality. Vascular calcification (VC) is a systemic disease with multifaceted contributing and inhibiting factors in an actively regulated process. The exact underlying mechanisms are not fully elucidated and reliable treatment options are lacking. Due to the complex pathophysiology, various research models exist evaluating different aspects of VC. This review aims to give an overview of the cell and animal models used so far to study the molecular processes of VC. Here, in vitro cell culture models of different origins, ex vivo settings using aortic tissue and various in vivo disease-induced animal models are summarized. They reflect different aspects and depict the (patho)physiologic mechanisms within the VC process. View Full-Text
Keywords: vascular calcification; in vitro; ex vivo; in vivo vascular calcification; in vitro; ex vivo; in vivo
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MDPI and ACS Style

Herrmann, J.; Babic, M.; Tölle, M.; van der Giet, M.; Schuchardt, M. Research Models for Studying Vascular Calcification. Int. J. Mol. Sci. 2020, 21, 2204.

AMA Style

Herrmann J, Babic M, Tölle M, van der Giet M, Schuchardt M. Research Models for Studying Vascular Calcification. International Journal of Molecular Sciences. 2020; 21(6):2204.

Chicago/Turabian Style

Herrmann, Jaqueline, Milen Babic, Markus Tölle, Markus van der Giet, and Mirjam Schuchardt. 2020. "Research Models for Studying Vascular Calcification" International Journal of Molecular Sciences 21, no. 6: 2204.

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