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Article

A Stochastic Petri Net-Based Model of the Involvement of Interleukin 18 in Atherosclerosis

1
Department of Clinical Biochemistry and Laboratory Medicine, Poznan University of Medical Sciences, 60-806 Poznan, Poland
2
Institute of Computing Science, Poznan University of Technology, 60-965 Poznan, Poland
3
Institute of Bioorganic Chemistry, Polish Academy of Sciences, 61-704 Poznan, Poland
4
Faculty of Electrical Engineering, Gdynia Maritime University, 81-225 Gdynia, Poland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(22), 8574; https://doi.org/10.3390/ijms21228574
Received: 1 October 2020 / Revised: 2 November 2020 / Accepted: 10 November 2020 / Published: 13 November 2020
Interleukin 18 (IL-18) is a proinflammatory and proatherogenic cytokine with pleiotropic properties, which is involved in T and NK cell maturation and the synthesis of other inflammatory cytokines and cell adhesion molecules. It plays a significant role in orchestrating the cytokine cascade, accelerates atherosclerosis and influences plaque vulnerability. To investigate the influence of IL-18 cytokine on atherosclerosis development, a stochastic Petri net model was built and then analyzed. First, MCT-sets and t-clusters were generated, then knockout and simulation-based analysis was conducted. The application of systems approach that was used in this research enabled an in-depth analysis of the studied phenomenon. Our results gave us better insight into the studied phenomenon and allow revealing that activation of macrophages by the classical pathway and IL-18-MyD88 signaling axis is crucial for the modeled process. View Full-Text
Keywords: atherosclerosis; inflammation; mathematical modeling; Petri net; stochastic Petri net; t-invariants atherosclerosis; inflammation; mathematical modeling; Petri net; stochastic Petri net; t-invariants
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MDPI and ACS Style

Formanowicz, D.; Rybarczyk, A.; Radom, M.; Tanaś, K.; Formanowicz, P. A Stochastic Petri Net-Based Model of the Involvement of Interleukin 18 in Atherosclerosis. Int. J. Mol. Sci. 2020, 21, 8574. https://doi.org/10.3390/ijms21228574

AMA Style

Formanowicz D, Rybarczyk A, Radom M, Tanaś K, Formanowicz P. A Stochastic Petri Net-Based Model of the Involvement of Interleukin 18 in Atherosclerosis. International Journal of Molecular Sciences. 2020; 21(22):8574. https://doi.org/10.3390/ijms21228574

Chicago/Turabian Style

Formanowicz, Dorota, Agnieszka Rybarczyk, Marcin Radom, Krzysztof Tanaś, and Piotr Formanowicz. 2020. "A Stochastic Petri Net-Based Model of the Involvement of Interleukin 18 in Atherosclerosis" International Journal of Molecular Sciences 21, no. 22: 8574. https://doi.org/10.3390/ijms21228574

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