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Review

From Grafts to Human Bioengineered Vascularized Skin Substitutes

1
Cell Production and Tissue Engineering Unit, Virgen de las Nieves University Hospital, 18014 Granada, Spain
2
Biosanitary Institute of Granada (ibs. GRANADA), 18014 Granada, Spain
3
Andalusian Network of Design and Translation of Advanced Therapies, 41092 Sevilla, Spain
4
Dermatology Department, Virgen de las Nieves University Hospital, 18014 Granada, Spain
5
Dermatology Department, School of Medicine, Granada University, 18016 Granada, Spain
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(21), 8197; https://doi.org/10.3390/ijms21218197
Received: 30 September 2020 / Revised: 27 October 2020 / Accepted: 29 October 2020 / Published: 2 November 2020
(This article belongs to the Special Issue Inflammatory Skin Conditions 2020)
The skin plays an important role in the maintenance of the human’s body physiological homeostasis. It acts as a coverage that protects against infective microorganism or biomechanical impacts. Skin is also implied in thermal regulation and fluid balance. However, skin can suffer several damages that impede normal wound-healing responses and lead to chronic wounds. Since the use of autografts, allografts, and xenografts present source limitations and intense rejection associated problems, bioengineered artificial skin substitutes (BASS) have emerged as a promising solution to address these problems. Despite this, currently available skin substitutes have many drawbacks, and an ideal skin substitute has not been developed yet. The advances that have been produced on tissue engineering techniques have enabled improving and developing new arising skin substitutes. The aim of this review is to outline these advances, including commercially available skin substitutes, to finally focus on future tissue engineering perspectives leading to the creation of autologous prevascularized skin equivalents with a hypodermal-like layer to achieve an exemplary skin substitute that fulfills all the biological characteristics of native skin and contributes to wound healing. View Full-Text
Keywords: angiogenesis; endothelial cells; grafts; skin substitutes; tissue engineering; trilayered; vascularization; wound healing angiogenesis; endothelial cells; grafts; skin substitutes; tissue engineering; trilayered; vascularization; wound healing
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MDPI and ACS Style

Oualla-Bachiri, W.; Fernández-González, A.; Quiñones-Vico, M.I.; Arias-Santiago, S. From Grafts to Human Bioengineered Vascularized Skin Substitutes. Int. J. Mol. Sci. 2020, 21, 8197. https://doi.org/10.3390/ijms21218197

AMA Style

Oualla-Bachiri W, Fernández-González A, Quiñones-Vico MI, Arias-Santiago S. From Grafts to Human Bioengineered Vascularized Skin Substitutes. International Journal of Molecular Sciences. 2020; 21(21):8197. https://doi.org/10.3390/ijms21218197

Chicago/Turabian Style

Oualla-Bachiri, Wasima, Ana Fernández-González, María I. Quiñones-Vico, and Salvador Arias-Santiago. 2020. "From Grafts to Human Bioengineered Vascularized Skin Substitutes" International Journal of Molecular Sciences 21, no. 21: 8197. https://doi.org/10.3390/ijms21218197

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