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Article

Surface Modification by Nano-Structures Reduces Viable Bacterial Biofilm in Aerobic and Anaerobic Environments

1
Department of Oral Biology, The Goldschleger School of Dental Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel
2
The Center for Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv 6997801, Israel
3
The Center for the Physics and Chemistry of Living Systems, Tel Aviv University, Tel Aviv 6997801, Israel
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(19), 7370; https://doi.org/10.3390/ijms21197370
Received: 15 September 2020 / Revised: 27 September 2020 / Accepted: 1 October 2020 / Published: 6 October 2020
Bacterial biofilm formation on wet surfaces represents a significant problem in medicine and environmental sciences. One of the strategies to prevent or eliminate surface adhesion of organisms is surface modification and coating. However, the current coating technologies possess several drawbacks, including limited durability, low biocompatibility and high cost. Here, we present a simple antibacterial modification of titanium, mica and glass surfaces using self-assembling nano-structures. We have designed two different nano-structure coatings composed of fluorinated phenylalanine via the drop-cast coating technique. We investigated and characterized the modified surfaces by scanning electron microscopy, X-ray diffraction and wettability analyses. Exploiting the antimicrobial property of the nano-structures, we successfully hindered the viability of Streptococcus mutans and Enterococcus faecalis on the coated surfaces in both aerobic and anaerobic conditions. Notably, we found lower bacteria adherence to the coated surfaces and a reduction of 86–99% in the total metabolic activity of the bacteria. Our results emphasize the interplay between self-assembly and antimicrobial activity of small self-assembling molecules, thus highlighting a new approach of biofilm control for implementation in biomedicine and other fields. View Full-Text
Keywords: modified amino acid; self-assembly; surface coating; anti-biofilm activity modified amino acid; self-assembly; surface coating; anti-biofilm activity
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MDPI and ACS Style

Ya’ari, S.; Halperin-Sternfeld, M.; Rosin, B.; Adler-Abramovich, L. Surface Modification by Nano-Structures Reduces Viable Bacterial Biofilm in Aerobic and Anaerobic Environments. Int. J. Mol. Sci. 2020, 21, 7370. https://doi.org/10.3390/ijms21197370

AMA Style

Ya’ari S, Halperin-Sternfeld M, Rosin B, Adler-Abramovich L. Surface Modification by Nano-Structures Reduces Viable Bacterial Biofilm in Aerobic and Anaerobic Environments. International Journal of Molecular Sciences. 2020; 21(19):7370. https://doi.org/10.3390/ijms21197370

Chicago/Turabian Style

Ya’ari, Sarah, Michal Halperin-Sternfeld, Boris Rosin, and Lihi Adler-Abramovich. 2020. "Surface Modification by Nano-Structures Reduces Viable Bacterial Biofilm in Aerobic and Anaerobic Environments" International Journal of Molecular Sciences 21, no. 19: 7370. https://doi.org/10.3390/ijms21197370

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