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Phage Display to Augment Biomaterial Function

1
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA
2
Department of Biologic and Material Sciences, University of Michigan, Ann Arbor, MI 48109, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(17), 5994; https://doi.org/10.3390/ijms21175994
Received: 11 July 2020 / Revised: 11 August 2020 / Accepted: 11 August 2020 / Published: 20 August 2020
(This article belongs to the Special Issue Bacteriophage—Molecular Studies 2.0)
Biomaterial design relies on controlling interactions between materials and their biological environments to modulate the functions of proteins, cells, and tissues. Phage display is a powerful tool that can be used to discover peptide sequences with high affinity for a desired target. When incorporated into biomaterial design, peptides identified via phage display can functionalize material surfaces to control the interaction between a biomaterial and its local microenvironment. A targeting peptide has high specificity for a given target, allowing for homing a specific protein, cell, tissue, or other material to a biomaterial. A functional peptide has an affinity for a given protein, cell, or tissue, but also modulates its target’s activity upon binding. Biomaterials can be further enhanced using a combination of targeting and/or functional peptides to create dual-functional peptides for bridging two targets or modulating the behavior of a specific protein or cell. This review will examine current and future applications of phage display for the augmentation of biomaterials. View Full-Text
Keywords: phage display; tissue engineering; biomaterials; dual-functioning peptides; peptides phage display; tissue engineering; biomaterials; dual-functioning peptides; peptides
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MDPI and ACS Style

Davidson, T.A.; McGoldrick, S.J.; Kohn, D.H. Phage Display to Augment Biomaterial Function. Int. J. Mol. Sci. 2020, 21, 5994. https://doi.org/10.3390/ijms21175994

AMA Style

Davidson TA, McGoldrick SJ, Kohn DH. Phage Display to Augment Biomaterial Function. International Journal of Molecular Sciences. 2020; 21(17):5994. https://doi.org/10.3390/ijms21175994

Chicago/Turabian Style

Davidson, Thomas A., Samantha J. McGoldrick, and David H. Kohn 2020. "Phage Display to Augment Biomaterial Function" International Journal of Molecular Sciences 21, no. 17: 5994. https://doi.org/10.3390/ijms21175994

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