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Article

Tau Gene Deletion Does Not Influence Axonal Regeneration and Retinal Neuron Survival in the Injured Mouse Visual System

CUO-Recherche, Département d’ophtalmologie, Faculté de médecine, Université Laval and Centre de recherche du CHU de Québec-Université Laval, Quebec, QC G1V 0A6, Canada
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Int. J. Mol. Sci. 2020, 21(11), 4100; https://doi.org/10.3390/ijms21114100
Received: 9 May 2020 / Revised: 3 June 2020 / Accepted: 5 June 2020 / Published: 8 June 2020
(This article belongs to the Special Issue Molecular Mechanisms of Neural Circuit Development and Regeneration)
In the present study, we hypothesized that the microtubule-associated protein Tau may influence retinal neuron survival and axonal regeneration after optic nerve injury. To test this hypothesis, the density of retinal ganglion cells was evaluated by immunostaining retinal flat-mounts for RNA-binding protein with multiple splicing (RBPMS) two weeks after optic nerve micro-crush lesion in Tau-deprived (Tau knock-out (KO)) and wild-type (WT) mice. Axon growth was determined on longitudinal sections of optic nerves after anterograde tracing. Our results showed that the number of surviving retinal ganglion cells and growing axons did not significantly vary between WT and Tau KO animals. Moreover, sustained activation of the neuronal growth program with ciliary neurotrophic factor (CNTF) resulted in a similar increase in surviving neurons and in growing axons in WT and Tau KO mice. Taken together, our data suggest that Tau does not influence axonal regeneration or neuronal survival. View Full-Text
Keywords: Tau; retina; optic nerve crush; retinal ganglion cell survival; axonal regeneration; CNTF Tau; retina; optic nerve crush; retinal ganglion cell survival; axonal regeneration; CNTF
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MDPI and ACS Style

Rodriguez, L.; Joly, S.; Mdzomba, J.B.; Pernet, V. Tau Gene Deletion Does Not Influence Axonal Regeneration and Retinal Neuron Survival in the Injured Mouse Visual System. Int. J. Mol. Sci. 2020, 21, 4100. https://doi.org/10.3390/ijms21114100

AMA Style

Rodriguez L, Joly S, Mdzomba JB, Pernet V. Tau Gene Deletion Does Not Influence Axonal Regeneration and Retinal Neuron Survival in the Injured Mouse Visual System. International Journal of Molecular Sciences. 2020; 21(11):4100. https://doi.org/10.3390/ijms21114100

Chicago/Turabian Style

Rodriguez, Léa, Sandrine Joly, Julius B. Mdzomba, and Vincent Pernet. 2020. "Tau Gene Deletion Does Not Influence Axonal Regeneration and Retinal Neuron Survival in the Injured Mouse Visual System" International Journal of Molecular Sciences 21, no. 11: 4100. https://doi.org/10.3390/ijms21114100

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