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Rewarming Injury after Cold Preservation

Department for Surgical Research, University Hospital Essen, Hufelandstr. 55, D-45147 Essen, Germany
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(9), 2059; https://doi.org/10.3390/ijms20092059
Received: 12 March 2019 / Revised: 5 April 2019 / Accepted: 24 April 2019 / Published: 26 April 2019
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PDF [374 KB, uploaded 26 April 2019]
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Abstract

Organ dysfunction pertinent to tissue injury related to ischemic ex vivo preservation during transport from donor to recipient still represents a pivotal impediment in transplantation medicine. Cold storage under anoxic conditions minimizes metabolic activity, but eventually cannot prevent energetic depletion and impairment of cellular signal homeostasis. Reoxygenation of anoxically injured tissue may trigger additional damage to the graft, e.g., by abundant production of oxygen free radicals upon abrupt reactivation of a not yet equilibrated cellular metabolism. Paradoxically, this process is driven by the sudden restoration of normothermic conditions upon reperfusion and substantially less pronounced during re-oxygenation in the cold. The massive energy demand associated with normothermia is not met by the cellular systems that still suffer from hypothermic torpor and dys-equilibrated metabolites and eventually leads to mitochondrial damage, induction of apoptosis and inflammatory responses. This rewarming injury is partly alleviated by preceding supply of oxygen already in the cold but more effectively counteracted by an ensuing controlled and slow oxygenated warming up of the organ prior to implantation. A gentle restitution of metabolic turnover rates in line with the resumption of enzyme kinetics and molecular homeostasis improves post transplantation graft function and survival. View Full-Text
Keywords: temperature paradox; rewarming injury; organ preservation; controlled rewarming; COR temperature paradox; rewarming injury; organ preservation; controlled rewarming; COR
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Minor, T.; von Horn, C. Rewarming Injury after Cold Preservation. Int. J. Mol. Sci. 2019, 20, 2059.

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