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Article

Infiltration of T Cells into a Three-Dimensional Psoriatic Skin Model Mimics Pathological Key Features

1
Centre de recherche en Organogénèse Expérimentale de l’Université Laval/LOEX, Axe Médecine Régénératrice, Centre de Recherche du CHU de Québec, Université Laval, Québec, QC G1J 1Z4, Canada
2
Faculté de Pharmacie, Université Laval, Québec, QC G1V 0A6, Canada
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(7), 1670; https://doi.org/10.3390/ijms20071670
Received: 5 March 2019 / Revised: 29 March 2019 / Accepted: 1 April 2019 / Published: 3 April 2019
(This article belongs to the Special Issue Molecular Mechanisms and Pathology of Psoriasis)
Psoriasis is an autoimmune chronic dermatosis that is T cell-mediated, characterized by epidermal thickening, aberrant epidermal differentiation and inflammatory infiltrates, with a dominant Th1 and Th17 profile. Additional in vitro models are required to study the complex interactions between activated T cells and skin cells, and to develop new, more effective treatments. We have therefore sought to model this psoriatic inflammation by the generation of tissue-engineered immunocompetent tissues, and we have investigated the response of activated T-cell infiltration in models produced with lesional psoriatic skin cells on major hallmarks of psoriasis. The immunocompetent lesional skin model displayed a delayed onset of epidermal differentiation, an hyperproliferation of the basal keratinocytes, a drastic increase in the secretion of proinflammatory cytokines, and a disturbed expression of key transcription factors, as observed in lesional plaques, suggesting a crucial importance of combining the pathological phenotype of cutaneous cells to T cells in order to generate a relevant model for psoriasis. Finally, we found this skin model to be responsive to methotrexate treatment, making it a valuable tool for drug development. View Full-Text
Keywords: psoriasis; T cells; adaptive immunity; inflammation; 3D model; tissue engineering psoriasis; T cells; adaptive immunity; inflammation; 3D model; tissue engineering
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MDPI and ACS Style

Lorthois, I.; Simard, M.; Morin, S.; Pouliot, R. Infiltration of T Cells into a Three-Dimensional Psoriatic Skin Model Mimics Pathological Key Features. Int. J. Mol. Sci. 2019, 20, 1670. https://doi.org/10.3390/ijms20071670

AMA Style

Lorthois I, Simard M, Morin S, Pouliot R. Infiltration of T Cells into a Three-Dimensional Psoriatic Skin Model Mimics Pathological Key Features. International Journal of Molecular Sciences. 2019; 20(7):1670. https://doi.org/10.3390/ijms20071670

Chicago/Turabian Style

Lorthois, Isabelle, Mélissa Simard, Sophie Morin, and Roxane Pouliot. 2019. "Infiltration of T Cells into a Three-Dimensional Psoriatic Skin Model Mimics Pathological Key Features" International Journal of Molecular Sciences 20, no. 7: 1670. https://doi.org/10.3390/ijms20071670

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