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Review

Ion Channels Involved in Substance P-Mediated Nociception and Antinociception

1
Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan
2
Taiwan Mouse Clinic, National Comprehensive Mouse Phenotyping and Drug Testing Center, Taipei 115, Taiwan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(7), 1596; https://doi.org/10.3390/ijms20071596
Received: 5 March 2019 / Revised: 26 March 2019 / Accepted: 27 March 2019 / Published: 30 March 2019
(This article belongs to the Special Issue Ion Channels of Nociception)
Substance P (SP), an 11-amino-acid neuropeptide, has long been considered an effector of pain. However, accumulating studies have proposed a paradoxical role of SP in anti-nociception. Here, we review studies of SP-mediated nociception and anti-nociception in terms of peptide features, SP-modulated ion channels, and differential effector systems underlying neurokinin 1 receptors (NK1Rs) in differential cell types to elucidate the effect of SP and further our understanding of SP in anti-nociception. Most importantly, understanding the anti-nociceptive SP-NK1R pathway would provide new insights for analgesic drug development. View Full-Text
Keywords: substance P; NK1R; nociception; anti-nociception; pain substance P; NK1R; nociception; anti-nociception; pain
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MDPI and ACS Style

Chang, C.-T.; Jiang, B.-Y.; Chen, C.-C. Ion Channels Involved in Substance P-Mediated Nociception and Antinociception. Int. J. Mol. Sci. 2019, 20, 1596. https://doi.org/10.3390/ijms20071596

AMA Style

Chang C-T, Jiang B-Y, Chen C-C. Ion Channels Involved in Substance P-Mediated Nociception and Antinociception. International Journal of Molecular Sciences. 2019; 20(7):1596. https://doi.org/10.3390/ijms20071596

Chicago/Turabian Style

Chang, Chu-Ting, Bo-Yang Jiang, and Chih-Cheng Chen. 2019. "Ion Channels Involved in Substance P-Mediated Nociception and Antinociception" International Journal of Molecular Sciences 20, no. 7: 1596. https://doi.org/10.3390/ijms20071596

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