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Resveratrol as a Tumor-Suppressive Nutraceutical Modulating Tumor Microenvironment and Malignant Behaviors of Cancer

1
Biomodulation, Department of Agricultural Biotechnology, Seoul National University, Seoul 08826, Korea
2
Cancer Research Institute, College of Medicine, Seoul National University, Seoul 03080, Korea
3
Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul 03080, Korea
4
Stephenson Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma city, OK 73012, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(4), 925; https://doi.org/10.3390/ijms20040925
Received: 1 February 2019 / Revised: 17 February 2019 / Accepted: 18 February 2019 / Published: 20 February 2019
(This article belongs to the Special Issue Health Benefits of Resveratrol)
Tumor-suppressive effects of resveratrol have been shown in various types of cancer. However, regulation of tumor microenvironment by resveratrol is still unclear. Recent findings suggest resveratrol can potentiate its tumor-suppressive effect through modulation of the signaling pathways of cellular components (fibroblasts, macrophages and T cells). Also, studies have shown that resveratrol can suppress malignant phenotypes of cancer cells acquired in response to stresses of the tumor microenvironment, such as hypoxia, oxidative stress and inflammation. We discuss the effects of resveratrol on cancer cells in stress environment of tumors as well as interactions between cancer cells and non-cancer cells in this review. View Full-Text
Keywords: resveratrol; tumor microenvironment; cancer; chemoresistance; metastasis resveratrol; tumor microenvironment; cancer; chemoresistance; metastasis
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MDPI and ACS Style

Han, Y.; Jo, H.; Cho, J.H.; Dhanasekaran, D.N.; Song, Y.S. Resveratrol as a Tumor-Suppressive Nutraceutical Modulating Tumor Microenvironment and Malignant Behaviors of Cancer. Int. J. Mol. Sci. 2019, 20, 925.

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