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Adiponectin as Link Factor between Adipose Tissue and Cancer

Department of Medicine and Health Sciences “V. Tiberio”, University of Molise, Campobasso 86100, Italy
Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, Naples 80131, Italy
Dipartimento di Scienze e Tecnologie Ambientali Biologiche Farmaceutiche, Università degli Studi della Campania “Luigi Vanvitelli”, Caserta 81100, Italy
CEINGE-Biotecnologie Avanzate Scarl, Napoli 80145, Italy
Dipartimento di Scienze Cardio-Toraciche e Respiratorie, Università degli Studi della Campania “Luigi Vanvitelli”, Napoli 80131, Italy
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(4), 839;
Received: 30 November 2018 / Revised: 9 February 2019 / Accepted: 11 February 2019 / Published: 15 February 2019
PDF [1407 KB, uploaded 15 February 2019]


Adipose tissue is a key regulator of energy balance playing an active role in lipid storage as well as in synthesizing several hormones directly involved in the pathogenesis of obesity. Obesity represents a peculiar risk factor for a growing list of cancers and is frequently associated to poor clinical outcome. The mechanism linking obesity and cancer is not completely understood, but, amongst the major players, there are both chronic low-grade inflammation and deregulation of adipokines secretion. In obesity, the adipose tissue is pervaded by an abnormal number of immune cells that create an inflammatory environment supporting tumor cell proliferation and invasion. Adiponectin (APN), the most abundant adipokine, shows anti-inflammatory, anti-proliferative and pro-apoptotic properties. Circulating levels of APN are drastically decreased in obesity, suggesting that APN may represent the link factor between obesity and cancer risk. The present review describes the recent advances on the involvement of APN and its receptors in the etiology of different types of cancer. View Full-Text
Keywords: Adiponectin; cancer; Adiponectin receptors; obesity; inflammatory response; inflammation; nutritional status Adiponectin; cancer; Adiponectin receptors; obesity; inflammatory response; inflammation; nutritional status

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Di Zazzo, E.; Polito, R.; Bartollino, S.; Nigro, E.; Porcile, C.; Bianco, A.; Daniele, A.; Moncharmont, B. Adiponectin as Link Factor between Adipose Tissue and Cancer. Int. J. Mol. Sci. 2019, 20, 839.

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