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Open AccessArticle

Loliolide Presents Antiapoptosis and Antiscratching Effects in Human Keratinocytes

1
Department of Biocosmetics, Sungkyunkwan University, Suwon 16419, Korea
2
Samcheok Prasiola Japonica Research Center, Samcheok City Hall, Samcheok 25914, Korea
3
Research and Business Foundation, Sungkyunkwan University, Suwon 16419, Korea
4
Department of Integrative Biotechnology, Sungkyunkwan University, Suwon 16419, Korea
5
Department of Veterinary Physiology, College of Medicine, Chonbuk National University, Iksan 54596, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(3), 651; https://doi.org/10.3390/ijms20030651
Received: 30 December 2018 / Revised: 23 January 2019 / Accepted: 31 January 2019 / Published: 2 February 2019
(This article belongs to the Section Biochemistry)
Loliolide is a monoterpenoid hydroxylactone present in freshwater algae that has anti-inflammatory and antiaging activity; however, its effects on ultraviolet-damaged skin have yet to be elucidated. This study investigated the antiapoptosis and wound-healing effects of loliolide using HaCaT cells (a human keratinocyte cell line). Loliolide inhibited the expression of reactive oxygen species (ROS) induced by ultraviolet radiation as well as wrinkle formation-related matrix metalloproteinase genes and increased the expression of the damage repair-related gene SIRT1. The apoptosis signaling pathway was confirmed by Western blot analysis, which showed that loliolide was able to reduce the expression of caspases 3, 8, and 9, which are related to ROS-induced apoptosis. In addition, Western blotting, reverse-transcription polymerase chain reaction (PCR), and real-time PCR analyses showed that loliolide enhanced the expression of the epidermal growth factor receptor signaling pathway (PI3K, AKT) and migration factors, such as K6, K16, and K17; keratinocyte growth factor; and inflammatory cytokines, such as interleukin (IL)-1, IL-17, and IL-22 expressed during the cellular scratching process, suggesting a putative wound-healing ability. Because of the antiapoptosis and antiscratching effects on skin of both loliolide and loliolide-rich Prasiola japonica ethanol extract, we consider the former to be an important compound used in the cosmeceutical industry. View Full-Text
Keywords: antiapoptosis; antiscratching effect; antiwrinkling activity; antioxidant activity antiapoptosis; antiscratching effect; antiwrinkling activity; antioxidant activity
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Park, S.H.; Kim, D.S.; Kim, S.; Lorz, L.R.; Choi, E.; Lim, H.Y.; Hossain, M.A.; Jang, S.; Choi, Y.I.; Park, K.J.; Yoon, K.; Kim, J.-H.; Cho, J.Y. Loliolide Presents Antiapoptosis and Antiscratching Effects in Human Keratinocytes. Int. J. Mol. Sci. 2019, 20, 651.

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