Windup of Nociceptive Flexion Reflex Depends on Synaptic and Intrinsic Properties of Dorsal Horn Neurons in Adult Rats
Abstract
:1. Introduction
2. Results
2.1. Windup of WDR Neurons and of the Flexion Reflex Share Similar Characteristics
2.2. Windup of the Nociceptive Flexion Reflex in Adult Rats is Controlled by Synaptic and Intrinsic Components
2.3. Windup of the Flexion Reflex Is Sensitive to IL Blockers in Adult Rats
2.4. Synaptic Component of Windup in DHNs of Adult Rats
2.5. LTCs Component of Windup in DHN in Adult Rats
3. Discussion
3.1. Adult and Juvenile Windup
3.2. Importance of LTCs in Windup
3.3. Synaptic Component of Windup
3.4. Neural Substrate of Windup
3.5. Windup and Central Sensitization to Pain
4. Methods
4.1. Experimental Procedures
4.2. Drug Administration
4.3. In Vivo Electromyographic Recordings
4.4. In Vivo Extracellular Recordings
4.5. Windup Protocol
4.6. Data Analysis and Statistics
Author Contributions
Funding
Conflicts of Interest
References
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Aby, F.; Bouali-Benazzouz, R.; Landry, M.; Fossat, P. Windup of Nociceptive Flexion Reflex Depends on Synaptic and Intrinsic Properties of Dorsal Horn Neurons in Adult Rats. Int. J. Mol. Sci. 2019, 20, 6146. https://doi.org/10.3390/ijms20246146
Aby F, Bouali-Benazzouz R, Landry M, Fossat P. Windup of Nociceptive Flexion Reflex Depends on Synaptic and Intrinsic Properties of Dorsal Horn Neurons in Adult Rats. International Journal of Molecular Sciences. 2019; 20(24):6146. https://doi.org/10.3390/ijms20246146
Chicago/Turabian StyleAby, Franck, Rabia Bouali-Benazzouz, Marc Landry, and Pascal Fossat. 2019. "Windup of Nociceptive Flexion Reflex Depends on Synaptic and Intrinsic Properties of Dorsal Horn Neurons in Adult Rats" International Journal of Molecular Sciences 20, no. 24: 6146. https://doi.org/10.3390/ijms20246146